| Autor: |
Bagdas, Deniz, Targowska-Duda, Katarzyna M., Lopez, Jhon J., Perez, Edwin G., Arias, Hugo R., Damaj, M. Imad |
| Rok vydání: |
2015 |
| Předmět: |
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| Popis: |
BACKGROUND: Positive allosteric modulators (PAMs) facilitate endogenous neurotransmission and/or enhance the efficacy of agonists without directly acting on the orthosteric binding sites. In this regard, selective 7 nicotinic acetylcholine receptor type II PAMs display antinociceptive activity in rodent chronic inflammatory and neuropathic pain models. This study investigates whether 3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2), a new putative 7-selective type II PAM, attenuates experimental inflammatory and neuropathic pains in mice. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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