| Autor: |
Aktas, Derya Anil, Akinalp, Gokcen, Sanli, Fatma, Yucel, Mehmet Ali, Gambacorta, Nicola, Nicolotti, Orazio, Karatas, Omer Faruk, Algul, Oztekin, Burmaoglu, Serdar |
| Rok vydání: |
2020 |
| Popis: |
The present study was carried out in the attempt to synthesize a new class of potential anticancer agents comprising eleven compounds (24-34) sharing the 3,5-diarylisoxazole as a core. The chemical structure of the new synthesized compounds was established by IR, H-1 NMR, C-13 NMR and elemental analysis. Their biological potential towards prostate cancer was evaluated by using cancer PC3 cells and non-tumorigenic PNT1a cells. Interestingly, compound 26 distinguished from others with a quite high selectivity value that is comparable to 5-FU. The binding mode of 26 towards Ribosomal protein S6 kinase beta-1 (S6K1) was investigated at a molecular level of detail by employing docking simulations based on GLIDE standard precision as well as MM-GBSA calculations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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