| Autor: |
Larsen, Jens V, Martinsen, Morten H, Mortensen, Martin B, Klausen, Ib C, Hedegaard, Berit S |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Larsen, J V, Martinsen, M H, Mortensen, M B, Klausen, I C & Hedegaard, B S 2020, ' Contemporary lipid clinic and achievements in low-density lipoprotein-cholesterol reductions in very high-risk patients ', Danish Medical Journal, vol. 68, no. 1, A08200610 . < https://ugeskriftet.dk/dmj/contemporary-lipid-clinic-and-achievements-low-density-lipoprotein-cholesterol-reductions-very-high > |
| Popis: |
INTRODUCTION: Numerous studies have shown that lowering of low-density lipoprotein-cholesterol (LDL-C) reduces the risk of cardiovascular disease (CVD). To optimise treatment, some patients are referred to a lipid clinic. The reduction in LDL-C achieved in a lipid clinic in contemporary practice is, however, not well described. The aim of the present study was to assess the LDL-C lowering effect among very high-risk patients with or without statin-associated muscle symptoms (SAMS) after treatment at a specialised lipid clinic endorsing European guidelines.METHODS: Medical records from 653 patients referred to our Lipid Clinic from 1 January 2013 to 1 May 2017 were examined retrospectively. Very high-risk patients were defined as either having CVD or diabetes mellitus Type 2 who were active smokers and/or had hypertension. The reduction in LDL-C and the number of patients reaching the LDL-C treatment target were investigated by comparing baseline data with the most recent values recorded.RESULTS: We identified 208 patients at a very high-risk for CVD. They obtained an LDL-C reduction of 23% corresponding to a reduction in LDL-C of 0.7 mmol/l (p less than 0.001). The percentage of patients reaching their LDL-C goal increased from 13% to 32%. In patients who had experienced SAMS, LDL-C was reduced by 26% corresponding to a reduction in LDL-C of 0.9 mmol/l (p less than 0.001), and the percentage of patients reaching their LDL-C goal increased from 8% to 23%.CONCLUSIONS: Very high-risk patients with or without SAMS obtained a clinically meaningful reduction in LDL-C of approximately 25% owing to their Lipid Clinic treatment.FUNDING: none.TRIAL REGISTRATION: not relevant. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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