| Autor: |
Bülow, S, Christensen, Ij, Iversen, L H, Harling, Henrik |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Zdroj: |
Bülow, S, Christensen, I, Iversen, L H & Harling, H 2010, ' Intraoperative perforation is an important predictor of local recurrence and impaired survival after abdominoperineal excision for rectal cancer ', Colorectal Disease . https://doi.org/10.1111/j.1463-1318.2010.02459.x |
| Popis: |
Aim: Abdominoperineal excision (APR) for rectal cancer is associated with higher rates of local recurrence and poorer survival than anterior resection. The aim of this study was to evaluate the outcome of conventional APR in a large national series. Method: The study was based on the Danish National Colorectal Cancer Database and included patients operated with APR from 1.5.2001-31.12.2006. A follow up in the departments was supplemented with vital status in the Civil Registration System. The analysis included actuarial local and distant recurrence and overall and cancer specific survival. Risk factors for local recurrence (LR), distant metastases (DM), overall survival (OS), and cancer specific survival (CS) were identified by multivariate analyses. Results: A total of 1.125 patients had a median follow-up of 57 (25-93) months. Intraoperative perforation occurred in 108 (10%). The cumulative 5-year LR rate was 11% (95% CI 7-13), OS was 56% (95% CI 53-60), and CS was 68% (95% CI 65-71). Multivariate analysis showed that perforation, tumour stage and non-radical surgery were independent risk factors for LR; tumour fixation, perforation and tumour stage were independent risk factors for DM, and risk factors for impaired OS and CS were age, tumour perforation, tumour stage, lymph node metastases and non-radical surgery. Conclusion: Intraoperative perforation is a major risk factor for local and distant recurrence and survival and should be avoided. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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