Abstract CT103: Final results for OptimalTTF-1: Optimizing Tumor Treating Fields with targeted skull remodeling surgery for first recurrence glioblastoma: Phase 1 trial:In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA)
| Autor: | Mikic, Nikola, Korshoej, Anders Rosendal, Lukacova, Slávka, Sørensen, Jens Christian Hedemann, Lundgaard Hansen, Frederik, Thielscher, Axel, Cortnum, Søren, Guldberg, Trine Lignell, Lassen, Yasmin Alexandra, Rahbek, Christian, Severinsen, Kåre, Oettingen, Gorm von |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Zdroj: | Mikic, N, Korshoej, A R, Lukacova, S, Sørensen, J C H, Lundgaard Hansen, F, Thielscher, A, Cortnum, S, Guldberg, T L, Lassen, Y A, Rahbek, C, Severinsen, K & Oettingen, G V 2020, ' Abstract CT103: Final results for OptimalTTF-1: Optimizing Tumor Treating Fields with targeted skull remodeling surgery for first recurrence glioblastoma: Phase 1 trial : In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): ', Cancer Research, vol. 80, no. 16, suppl., CT103 . https://doi.org/10.1158/1538-7445.AM2020-CT103 |
| DOI: | 10.1158/1538-7445.AM2020-CT103 |
| Popis: | We present a clinical open label, phase-1 trial (OptimalTTF-1, NCT02893137), which aims to test a novel treatment for first recurrence glioblastoma (rGBM). The aim of the treatment is to optimize the electric field generated by Tumor Treating Fields (TTFields) with targeted and individualized skull-remodeling surgery (SR-surgery). Selectively placed burrholes reduces the electric resistance created by the bone and thus improves the electric field focally. Preclinical research has indicated this conclusion. The final analysis examined the toxicity and efficacy of this combined intervention in addition to best practice chemotherapy. |
| Databáze: | OpenAIRE |
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