| Autor: |
Jinquan, T., Frydenberg, Jane, Mukaida, N., Bonde, J., Larsen, C.G., Matsushima, K., Thestrup-Pedersen, K. |
| Jazyk: |
angličtina |
| Rok vydání: |
1995 |
| Zdroj: |
Jinquan, T, Frydenberg, J, Mukaida, N, Bonde, J, Larsen, C G, Matsushima, K & Thestrup-Pedersen, K 1995, ' Recombinant human growth-regulated oncogene-α induces T lymphocyte chemotaxis : A process regulated via IL-8 receptors by IFN-γ, TNF-α, IL-4, IL-10, and IL-13 ', Journal of Immunology, vol. 155, no. 11, pp. 5359-5368 . |
| Popis: |
The human cytokine growth-regulated oncogene (GRO)-α is a small glycoprotein secreted by monocytes, endothelial cells, fibroblasts, synovial cells, and some tumor cells such as melanoma cells. It is structurally related to IL-8 and can activate neutrophils, whereas it induces chemotaxis, exocytosis, and a respiratory burst in neutrophils. To date, its functions on T lymphocytes have not been well established. We report here that recombinant human (rh)GRO-α is a potent chemoattractant for freshly isolated T lymphocytes, but not for anti-CD3 mAb-activated T lymphocytes. It attracts CD4 and CD8 T lymphocyte subsets to an equal extent. The migrating T lymphocytes toward rhGRO-α are predominantly CD45RO memory CD4 and CD8 subsets. The chemotactic migration of T lymphocytes toward rhGRO-α is stimulated via the IL-8 receptors on the cells. This process can be augmented by IFN-γ and TNF-α, and inhibited by IL-4, IL-10, and IL-13. In addition, we also document that on T lymphocytes there exist IL-8 receptors that can be up-regulated by IFN-γ, TNF-α, and IL-2. Our results demonstrate that rhGRO- α gene encodes for an inflammatory mediator that stimulates the directional migration of T lymphocytes. It may thus be another important mediator in the diseases in which T lymphocytes form the major constituent of the cellular infiltration. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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