| Autor: |
Rosthøj, Steen, Rajantie, Jukka, Treutiger, Iris, Zeller, Bernward, Tedgård, Ulf, Henter, Jan-Inge |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Zdroj: |
Rosthøj, S, Rajantie, J, Treutiger, I, Zeller, B, Tedgård, U, Henter, J-I & on behalf of the NOPHO ITP Working Group 2012, ' Duration and morbidity of chronic immune thrombocytopenic purpura in children : Five-year follow-up of a Nordic cohort ', Acta Paediatrica, vol. 101, no. 7, pp. 761-6 . https://doi.org/10.1111/j.1651-2227.2012.02671.x |
| DOI: |
10.1111/j.1651-2227.2012.02671.x |
| Popis: |
Aim: To describe the clinical course, morbidity and platelet recovery in an unselected Nordic cohort of children with chronic Immune Thrombocytopenic Purpura (ITP). Methods: Prospective 5-year follow-up of 96 children with ITP lasting more than 6 months, with reporting of hospital admissions, severity of bleeding episodes, and stabilization of platelet counts above 20, 50 and 150 x 10(9) /L. Results: The estimated 5-year recovery rate was 52%; exclusion of 12 splenectomized children did not change the estimate. Events eliciting admission to hospital occurred in 39 (41%). Major hemorrhages occurred in 8 children (8%), including a non-fatal intracranial hemorrhage in one child (1%). The overall admission rate was 0.4 per year of thrombocytopenia, decreasing during follow-up as thrombocytopenia converted to milder degrees. Early recovery within 2 years of diagnosis occurred in 35%, was associated with low morbidity, and was more likely in young children with abrupt onset of symptoms. Conclusion: In a Nordic cohort of children with chronic ITP one half had recovered 5 years after diagnosis, more than half never required hospitalization, and less than 10% experienced serious bleeding episodes, always with a platelet count |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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