Disruption of Na+,HCO₃⁻ cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca²⁺ sensitivity, and hypertension development in mice

Autor:	Boedtkjer, Ebbe, Prætorius, Jeppe, Matchkov, Vladimir V, Stankevicius, Edgaras, Mogensen, Susie, Füchtbauer, Annette C, Simonsen, Ulf, Füchtbauer, Ernst-Martin, Aalkjaer, Christian
Jazyk:	angličtina
Rok vydání:	2011
Předmět:	Mice Knockout Sodium-Bicarbonate Symporters Sodium-Hydrogen Antiporter Nitric Oxide Muscle Smooth Vascular Mesenteric Arteries Mice Inbred C57BL Vasodilation Mice Organ Culture Techniques Hypertension Animals Calcium Calcium Signaling Endothelium Vascular
Zdroj:	Boedtkjer, E, Prætorius, J, Matchkov, V V, Stankevicius, E, Mogensen, S, Füchtbauer, A C, Simonsen, U, Füchtbauer, E-M & Aalkjaer, C 2011, ' Disruption of Na+,HCO₃⁻ cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca²⁺ sensitivity, and hypertension development in mice ', Circulation, vol. 124, no. 17, pp. 1819-1829 . https://doi.org/10.1161/CIRCULATIONAHA.110.015974
DOI:	10.1161/CIRCULATIONAHA.110.015974
Popis:	Disturbances in pH affect artery function, but the mechanistic background remains controversial. We investigated whether Na(+), HCO₃- transporter NBCn1, by regulating intracellular pH(pH₁), influences artery function and blood pressure regulation.
Databáze:	OpenAIRE
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