Family occurrence of steroid-sensitive idiopathic nephrotic syndrome

Autor:	Tusgaard Petersen, Birgitte, Frydensbjerg Andersen, Rene, Rittig, Søren
Jazyk:	dánština
Rok vydání:	2012
Předmět:	Male Nephrotic Syndrome Biopsy Nephrosis Lipoid Prednisolone Intracellular Signaling Peptides and Proteins Membrane Proteins Kidney Tacrolimus Treatment Outcome Mutation Humans Female Genetic Predisposition to Disease Child Glucocorticoids Immunosuppressive Agents
Zdroj:	Tusgaard Petersen, B, Frydensbjerg Andersen, R & Rittig, S 2012, ' Familiaer forekomst af steroidsensitivt idiopatisk nefrotisk syndrom ', Ugeskrift for Laeger, bind 174, nr. 46, s. 2868-9 .
Popis:	Nephrotic syndrome (NS) presented within three weeks in siblings aged six and ten years. Both children experienced proteinuria, hypoalbuminaemia and oedema, with the most pronounced symptoms in the older. Standard treatment with prednisolone led to remission of the nephrotic syndrome in the younger, whereas the older required additional therapy with tacrolismus before remission. In view of the low incidence of NS in children, a near simultaneously onset in two siblings must lead to genetic elucidation. Genetic disorders and other causes of childhood NS are discussed.
Databáze:	OpenAIRE
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