Reduced dietary intake of micronutrients with antioxidant properties negatively impacts muscle health in aged mice
| Autor: | van Dijk, Miriam, Dijk, Francina J., Hartog, Anita, van Norren, Klaske, Verlaan, Sjors, van Helvoort, Ardy, Jaspers, Richard T., Luiking, Yvette |
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| Přispěvatelé: | RS: NUTRIM - R3 - Respiratory & Age-related Health, Bedrijfsbureau NTM, Internal medicine, Physiology, AMS - Ageing and Morbidity |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male lcsh:Diseases of the musculoskeletal system UBIQUITIN-CONJUGATING ENZYME TELETHONIN Antioxidants lcsh:QM1-695 Mice Young Adult Animals Humans E2 ENZYMES Micronutrients Function Muscle Skeletal SDG 2 - Zero Hunger GENE-EXPRESSION Nutrition DEPENDENT PROTEOLYSIS Muscle quality E3 LIGASE MURF1 PROTEIN LIGASES RAT SOLEUS MUSCLE Original Articles lcsh:Human anatomy Diet Mice Inbred C57BL RING-FINGER SKELETAL-MUSCLE Original Article Strength lcsh:RC925-935 |
| Zdroj: | van Dijk, M, Dijk, F J, Hartog, A, van Norren, K, Verlaan, S, van Helvoort, A, Jaspers, R T & Luiking, Y 2018, ' Reduced dietary intake of micronutrients with antioxidant properties negatively impacts muscle health in aged mice ', Journal of Cachexia, Sarcopenia and Muscle, vol. 9, no. 1, pp. 146-159 . https://doi.org/10.1002/jcsm.12237 Journal of cachexia, sarcopenia and muscle, 9(1), 146-159. Wiley Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 1, Pp 146-159 (2018) Journal of Cachexia, Sarcopenia and Muscle, 9(1), 146-159. Wiley-Blackwell Journal of Cachexia, Sarcopenia and Muscle Journal of Cachexia, Sarcopenia and Muscle, 9(1), 146-159. Springer Verlag |
| ISSN: | 2190-5991 2190-6009 |
| DOI: | 10.1002/jcsm.12237 |
| Popis: | Background: Inadequate intake of micronutrients with antioxidant properties is common among older adults and has been associated with higher risk of frailty, adverse functional outcome, and impaired muscle health. However, a causal relationship is less well known. The aim was to determine in old mice the impact of reduced dietary intake of vitamins A/E/B6/B12/folate, selenium, and zinc on muscle mass, oxidative capacity, strength, and physical activity (PA) over time. Methods: Twenty-one-month-old male mice were fed either AIN-93-M (control) or a diet low in micronutrients with antioxidant properties (=LOWOX-B: 50% of mouse recommended daily intake of vitamins A, E, B6, and B12, folate, selenium, and zinc) for 4 months. Muscle mass, grip strength, physical activity (PA), and general oxidative status were assessed. Moreover, muscle fatigue was measured of m. extensor digitorum longus (EDL) during an ex vivo moderate exercise protocol. Effects on oxidative capacity [succinate dehydrogenase (SDH) activity], muscle fibre type, number, and fibre cross-sectional area (fCSA) were assessed on m. plantaris (PL) using histochemistry. Results: After 2 months on the diet, bodyweight of LOWOX-B mice was lower compared with control (P |
| Databáze: | OpenAIRE |
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