Functionally asymmetric motor neurons contribute to coordinating locomotion of Caenorhabditis elegans
| Autor: | Tolstenkov, Oleg, Van der Auwera, Petrus, Steuer Costa, Wagner, Bazhanova, Olga, Gemeinhardt, Tim M, Bergs, Amelie CF, Gottschalk, Alexander |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Life Sciences & Biomedicine - Other Topics
TRANSMISSION QH301-705.5 Science ORGANIZATION MECHANISMS Animals Genetically Modified Ca2+ imaging MANIPULATION Interneurons Animals ddc:610 MODULATION Biology (General) Caenorhabditis elegans optogenetics Biology IN-VIVO gap junctions Motor Neurons behavioral analysis Science & Technology C.-ELEGANS Muscles NERVOUS-SYSTEM Cholinergic Neurons SPINAL CIRCUITS PATTERN GENERATION locomotor circuit C. elegans Medicine Life Sciences & Biomedicine Locomotion Research Article Neuroscience |
| Zdroj: | eLife, Vol 7 (2018) eLife |
| Popis: | Locomotion circuits developed in simple animals, and circuit motifs further evolved in higher animals. To understand locomotion circuit motifs, they must be characterized in many models. The nematode Caenorhabditis elegans possesses one of the best-studied circuits for undulatory movement. Yet, for 1/6th of the cholinergic motor neurons (MNs), the AS MNs, functional information is unavailable. Ventral nerve cord (VNC) MNs coordinate undulations, in small circuits of complementary neurons innervating opposing muscles. AS MNs differ, as they innervate muscles and other MNs asymmetrically, without complementary partners. We characterized AS MNs by optogenetic, behavioral and imaging analyses. They generate asymmetric muscle activation, enabling navigation, and contribute to coordination of dorso-ventral undulation as well as anterio-posterior bending wave propagation. AS MN activity correlated with forward and backward locomotion, and they functionally connect to premotor interneurons (PINs) for both locomotion regimes. Electrical feedback from AS MNs via gap junctions may affect only backward PINs. ispartof: ELIFE vol:7 ispartof: location:England status: published |
| Databáze: | OpenAIRE |
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