Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants
| Autor: | Hysaj, Ola, Marqués-Gallego, Patricia, Richard, Aline, Elgizouli, Magdeldin, Nieters, Alexandra, Quack Lötscher, Katharina C, Rohrmann, Sabine |
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| Přispěvatelé: | University of Zurich, Rohrmann, Sabine |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
10039 Institute of Medical Genetics Pregnancy Trimester Third 610 Medicine & health lcsh:TX341-641 vitamin D Article Young Adult Humans parathyroid hormone Life Style 10026 Clinic for Obstetrics 1106 Food Science determinants Vitamins 10060 Epidemiology Biostatistics and Prevention Institute (EBPI) Pregnancy Trimester First Cross-Sectional Studies Socioeconomic Factors 570 Life sciences biology 2916 Nutrition and Dietetics Female pregnancy lcsh:Nutrition. Foods and food supply Switzerland hormones hormone substitutes and hormone antagonists |
| Zdroj: | Nutrients Volume 13 Issue 2 Nutrients, Vol 13, Iss 360, p 360 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13020360 |
| Popis: | We aimed to assess the parathyroid hormone (PTH) concentration in pregnant women at the beginning of pregnancy (1st trimester) and within days before delivery (3rd trimester) and evaluate its determinants. From September 2014 through December 2015 in a cross-sectional study, 204 women in the 1st trimester of pregnancy and 203 women in the 3rd trimester of pregnancy were recruited. Blood samples were collected to measure PTH and circulating 25-hydroxy-vitamin D (25(OH)D) concentrations. Lifestyle and demographic data were collected using a questionnaire. Serum 25(OH)D and PTH were inversely correlated in both early and late pregnancy. Our analyses suggest that in the 3rd trimester of pregnancy, a 25(OH)D level of 18.9 ng/mL (47.3 nmol/L) could serve as an inflection point for the maximal suppression of PTH. Statistically significant determinants of PTH concentrations in multiple regression were 25(OH)D concentrations, season, multiparity and education of the partner (all p < 0.05) in early pregnancy. In late pregnancy, 25(OH)D concentrations and country of origin were statistically significant determinants of PTH concentrations (all p < 0.05). These factors and their effect on PTH appear to be vastly determined by 25(OH)D however, they might also affect PTH through other mechanisms besides 25(OH)D. |
| Databáze: | OpenAIRE |
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