Recurrence of Goodpasture syndrome without circulating anti-glomerular basement membrane antibodies after kidney transplant, a case report
| Autor: | Thibaud, V., Rioux-Leclercq, N., Vigneau, C., Morice, S. |
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| Přispěvatelé: | CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de Néphrologie (CH St Malo), CH de Saint-Malo, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Jonchère, Laurent |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Reoperation Anti-Glomerular Basement Membrane Disease Goodpasture syndrome (GS) [SDV]Life Sciences [q-bio] Kidney Glomerulus Case Report lcsh:RC870-923 urologic and male genital diseases Postoperative Complications Recurrence Renal Dialysis Glomerular Basement Membrane Living Donors Humans Kidney transplant Autoantibodies [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology Plasma Exchange urogenital system lcsh:Diseases of the genitourinary system. Urology Kidney Transplantation End-stage renal disease (ESRD) [SDV] Life Sciences [q-bio] Anti-glomerular basement membrane (GBM) disease Female Immunosuppressive Agents [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | BMC Nephrology BMC Nephrology, BioMed Central, 2019, 20 (1), pp.6. ⟨10.1186/s12882-018-1197-6⟩ BMC Nephrology, 2019, 20 (1), pp.6. ⟨10.1186/s12882-018-1197-6⟩ BMC Nephrology, Vol 20, Iss 1, Pp 1-5 (2019) |
| ISSN: | 1471-2369 |
| Popis: | International audience; Background - Goodpasture Syndrome (GS) is an autoimmune disease caused by the development of auto-antibodies against the Glomerular Basement Membrane (GBM). Linear deposit of immunoglobulins G on the GBM detected by immunofluorescence analysis of renal biopsies is a GS pathognomonic finding. GS is commonly monophasic and its incidence is 1.6 case per million per year. Case presentation - This report describes and discusses the case of a 40-year-old woman who one year after allograft kidney transplant, presented with acute pulmonary and renal symptoms of GS, leading to acute graft dysfunction, without circulating anti-GBM antibody detection in laboratory assays. She received a living donor kidney transplant 4 years after the first diagnosis of GS without circulating anti-GBM antibodies, when considered in remission. Conclusions - In both episodes, the diagnosis of GS was based exclusively on the kidney biopsy that showed rapidly progressing glomerulonephritis with deposition of immunoglobulins G on the GBM. Although rare, the management of patients with GS without circulating anti-GBM antibodies is difficult due to the lack of standardized follow-up guidelines to reduce the risk of GS recurrence after kidney transplantation. |
| Databáze: | OpenAIRE |
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