Biochemical effects of low level exposure to soman vapour

Autor:	Bajgar, J., Ševelová, L., Krejčová, G., Josef Fusek, Vachek, J., Kassa, J., Herink, J., Jong, L. P. A., Benschop, H.
Rok vydání:	2004
Předmět:	Inhalation Exposure Erythrocytes Behavior Animal Diaphragm Guinea Pigs Soman Brain Lethal Dose 50 Liver Butyrylcholinesterase Acetylcholinesterase Animals Cholinesterases Female Chemical Warfare Agents Cholinesterase Inhibitors Corticosterone Tyrosine Transaminase
Zdroj:	Europe PubMed Central Scopus-Elsevier
ISSN:	1210-7778
Popis:	The aim of this study was to demonstrate changes in acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities, tyrosine aminotransferase activity (TAT) and plasma corticosterone level, neuroexcitability and behavior following 24 hours and 4 weeks of soman sublethal inhalation exposure at low level. AChE activity in erythrocytes and BuChE activity in plasma was decreased (dependent on the concentration of soman) 24 h and 4 weeks after the exposure. Similar decrease in AChE activity in different brain parts was observed. One of stressogenic parameters (TAT) was changed after 24 h exposure only. 4 weeks after the exposure, these parameters (corticosterone and TAT) were in the range of normal values. Behaviour of experimental animals was changed 24 h after the exposure persisting 4 weeks after the exposure as well as neuroexcitability.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fb455fdefbd2de56ab4ad36dbaba5085 https://pubmed.ncbi.nlm.nih.gov/15141961 Zobrazit plný text záznamu