Rat sensorimotor cortex tolerance to parallel transections induced by synchrotron-generated X-ray microbeams
| Autor: | Fardone, Erminia, Bravin, Alberto, Conti, Alfredo, Bräuer-Krisch, Elke, Requardt, Herwig, Bucci, Domenico, Le Duc, Geraldine, Battaglia, Giuseppe, Romanelli, Pantaleo |
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| Přispěvatelé: | Fardone, Erminia, Bravin, Alberto, Conti, Alfredo, Bräuer-Krisch, Elke, Requardt, Herwig, Bucci, Domenico, Le Duc, Geraldine, Battaglia, Giuseppe, Romanelli, Pantaleo, Florida State University [Tallahassee] (FSU), European Synchrotron Radiation Facility (ESRF), Univ Messina, Dept Neurosurg, Messina, Italy, IRCCS Neuromed, Pozzilli, Italy, AB Med, Lainate, Italy, Cyberknife Ctr, Brain Radiosurg, Ctr Diagnost Italiano, Milan, Italy, Fardone, E, Bravin, A, Conti, A, Braeuer-Krisch, E, Requardt, H, Bucci, D, Le Duc, G, Battaglia, G, Romanelli, P |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
X-Rays/adverse effects [SDV]Life Sciences [q-bio] Brain Neoplasms/radiotherapy Sensorimotor Cortex/metabolism FIS/07 - FISICA APPLICATA (A BENI CULTURALI AMBIENTALI BIOLOGIA E MEDICINA) lcsh:Medicine rat brain synchrotron radiation microbeams Weight Gain Paresis/pathology Radiation Dosage Article Synchrotron Paralysis/pathology Animals Paralysis Gliosis Psychomotor Performance/radiation effect Rats Wistar lcsh:Science Sensorimotor Cortex/radiation effect Epilepsy MULTIPLE SUBPIAL TRANSECTIONS RADIATION-THERAPY MRT EPILEPTIFORM DISCHARGES CORTICAL TRANSECTIONS MICROPLANAR BEAMS RADIOSURGERY EPILEPSY NEOCORTEX BRAIN RADIOTHERAPY Brain Neoplasms Animal X-Rays lcsh:R equipment and supplies Epilepsy/radiotherapy Rats Paresis Gliosis/pathology Rat lcsh:Q Sensorimotor Cortex Weight Gain/radiation effect Psychomotor Performance Synchrotrons |
| Zdroj: | Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017) Scientific Reports Scientific Reports, Nature Publishing Group, 2017, 7, 7 p. ⟨10.1038/s41598-017-14757-3⟩ 'Scientific Reports ', vol: 7, pages: 14290-1-14290-7 (2017) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-017-14757-3⟩ |
| Popis: | International audience; Microbeam radiation therapy is a novel preclinical technique, which uses synchrotron-generated X-rays for the treatment of brain tumours and drug-resistant epilepsies. In order to safely translate this approach to humans, a more in-depth knowledge of the long-term radiobiology of microbeams in healthy tissues is required. We report here the result of the characterization of the rat sensorimotor cortex tolerance to microradiosurgical parallel transections. Healthy adult male Wistar rats underwent irradiation with arrays of parallel microbeams. Beam thickness, spacing and incident dose were 100 or 600 mu m, 400 or 1200 mu m and 360 or 150 Gy, respectively. Motor performance was carried over a 3-month period. Three months after irradiation rats were sacrificed to evaluate the effects of irradiation on brain tissues by histology and immunohistochemistry. Microbeam irradiation of sensorimotor cortex did not affect weight gain and motor performance. No gross signs of paralysis or paresis were also observed. The cortical architecture was not altered, despite the presence of cell death along the irradiation path. Reactive gliosis was evident in the microbeam path of rats irradiated with 150 Gy, whereas no increase was observed in rats irradiated with 360 Gy |
| Databáze: | OpenAIRE |
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