Effects of resveratrol on hydrogen peroxide-induced oxidative stress in embryonic neural stem cells
| Autor: | Konyalioglu, Sibel, Armagan, Guliz, Yalcin, Ayfer, Atalayin, Cigdem, Dagci, Taner |
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| Přispěvatelé: | Ege Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
nitric oxide synthase
grants-supported paper catalase hydrogen peroxide resveratrol Traditional Chinese Medicine and Neural Regeneration traditional Chinese medicine stem cells nitric oxide embryonic neural stem cells DNA damage neuroprotection neural regeneration glutathione peroxidase neuroregeneration |
| Zdroj: | Neural Regeneration Research |
| ISSN: | 0003-1593 |
| Popis: | WOS: 000315936300001 PubMed ID: 25206691 Resveratrol, a natural phenolic compound, has been shown to prevent cardiovascular diseases and cancer and exhibit neuroprotective effects. In this study, we examined the neuroprotective and antioxidant effects of resveratrol against hydrogen peroxide in embryonic neural stem cells. Hydrogen peroxide treatment alone increased catalase and glutathione peroxidase activities but did not change superoxide dismutase levels compared with hydrogen peroxide + resveratrol treatment. Nitric oxide synthase activity and concomitant nitric oxide levels increased in response to hydrogen peroxide treatment. Conversely, resveratrol treatment decreased nitric oxide synthase activity and nitric oxide levels. Resveratrol also attenuated hydrogen peroxide-induced nuclear or mitochondrial DNA damage. We propose that resveratrol may be a promising agent for protecting embryonic neural stem cells because of its potential to decrease oxidative stress by inducing higher activity of antioxidant enzymes, decreasing nitric oxide production and nitric oxide synthase activity, and alleviating both nuclear and mitochondrial DNA damage. Turkish Scientific and Technological Council (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK); Research Fund of Ege UniversityEge University [05/ECZ/020] Guliz Armagan acknowledges a scholarship for postgraduate students obtained from the Turkish Scientific and Technological Council (TUBITAK).; This study was funded by the Research Fund of Ege University, Project No. 05/ECZ/020. |
| Databáze: | OpenAIRE |
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