Sustained Inflammatory Signalling through Stat1/Stat2/IRF9 Is Associated with Amoeboid Phenotype of Melanoma Cells

Autor: Aneta, Gandalovičová, Anna-Marie, Šůchová, Vladimír, Čermák, Ladislav, Merta, Daniel, Rösel, Jan, Brábek
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Cancers
Volume 12
Issue 9
Cancers, Vol 12, Iss 2450, p 2450 (2020)
ISSN: 2072-6694
DOI: 10.3390/cancers12092450
Popis: The invasive behaviour of cancer cells underlies metastatic dissemination
however, due to the large plasticity of invasion modes, it is challenging to target. It is now widely accepted that various secreted cytokines modulate the tumour microenvironment and pro-inflammatory signalling can promote tumour progression. Here, we report that cells after mesenchymal&ndash
amoeboid transition show the increased expression of genes associated with the type I interferon response. Moreover, the sustained activation of type I interferon signalling in response to IFN&beta
mediated by the Stat1/Stat2/IRF9 complex enhances the round amoeboid phenotype in melanoma cells, whereas its downregulation by various approaches promotes the mesenchymal invasive phenotype. Overall, we demonstrate that interferon signalling is associated with the amoeboid phenotype of cancer cells and suggest a novel role of IFN&beta
in promoting cancer invasion plasticity, aside from its known role as a tumour suppressor.
Databáze: OpenAIRE
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