Impact of COPD diagnosis timing on clinical and economic outcomes : the ARCTIC observational cohort study
| Autor: | Larsson, Kjell, Janson, Christer, Ställberg, Björn, Lisspers, Karin, Olsson, Petter, Kostikas, Konstantinos, Gruenberger, Jean-Bernard, Gutzwiller, Florian S., Uhde, Milica, Jorgensen, Leif, Johansson, Gunnar |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Time Factors diagnosis Health Status Respiratory Medicine and Allergy Comorbidity International Journal of Chronic Obstructive Pulmonary Disease chronic obstructive pulmonary disease Pulmonary Disease Chronic Obstructive exacerbations Predictive Value of Tests Risk Factors Electronic Health Records Humans Original Research Aged Retrospective Studies Lungmedicin och allergi Sweden Primary Health Care Health Care Costs Prognosis mortality Early Diagnosis Disease Progression Female |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
| Popis: | Kjell Larsson,1 Christer Janson,2 Björn Ställberg,3 Karin Lisspers,3 Petter Olsson,4 Konstantinos Kostikas,5 Jean-Bernard Gruenberger,5 Florian S Gutzwiller,5 Milica Uhde,6 Leif Jorgensen,7 Gunnar Johansson31Work Environment Toxicology, Karolinska Institutet, Stockholm, Sweden; 2Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden; 3Public Health and Caring Sciences, Family Medicine and Preventive Medicine, Uppsala University, Uppsala, Sweden; 4Novartis AB, Täby, Sweden; 5Novartis Pharma AG, Basel, Switzerland; 6IQVIA, Solna, Sweden; 7IQVIA, Copenhagen, DenmarkPurpose: Assess the clinical and economic consequences associated with an early versus late diagnosis in patients with COPD.Patients and methods: In a retrospective, observational cohort study, electronic medical record data (2000–2014) were collected from Swedish primary care patients with COPD. COPD indicators (pneumonia, other respiratory diseases, oral corticosteroids, antibiotics for respiratory infections, prescribed drugs for respiratory symptoms, lung function measurement) registered prior to diagnosis were applied to categorize patients into those receiving early (2 or less indicators) or late diagnosis (3 or more indicators registered >90 days preceding a COPD diagnosis). Outcome measures included annual rate of and time to first exacerbation, mortality risk, prevalence of comorbidities and health care utilization.Results: More patients with late diagnosis (n=8827) than with early diagnosis (n=3870) had a recent comorbid diagnosis of asthma (22.0% vs 3.9%; P |
| Databáze: | OpenAIRE |
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