Increased prevalence of ECG markers for sudden cardiac arrest in refractory epilepsy
| Autor: | Lamberts, R. J., Blom, M. T., Novy, J., Belluzzo, M., Seldenrijk, A., Penninx, B. W., Sander, J. W., Tan, H. L., Thijs, R. D. |
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| Přispěvatelé: | ACS - Amsterdam Cardiovascular Sciences, APH - Amsterdam Public Health, Cardiology, EMGO+ - Mental Health, Psychiatry, EMGO - Mental health, NCA - Neurobiology of mental health |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Sudden Death Adolescent Statistics as Topic Drug Resistance Electrocardiography Young Adult SDG 3 - Good Health and Well-being Heart Rate Risk Factors Cause of Death Channels Humans cardiovascular diseases Aged Netherlands Anticonvulsants/therapeutic use Biological Markers Cross-Sectional Studies Death Sudden Cardiac/epidemiology Epilepsy/drug therapy Epilepsy/epidemiology Female Long QT Syndrome/drug therapy Long QT Syndrome/epidemiology Middle Aged Signal Processing Computer-Assisted Tachycardia Ventricular/drug therapy Tachycardia Ventricular/epidemiology Ventricular Fibrillation/drug therapy Ventricular Fibrillation/epidemiology Epilepsy Long QT Syndrome Death Sudden Cardiac Ventricular Fibrillation Tachycardia Ventricular Anticonvulsants Biomarkers |
| Zdroj: | Journal of neurology, neurosurgery, and psychiatry, 86(3), 309-313. BMJ Publishing Group Lamberts, R, Blom, M, Novy, J, Belluzzo, M, Seldenrijk, A, Penninx, B W J H, Sander, J, Tan, H L & Thijs, R 2015, ' Increased prevalence of ECG markers for sudden cardiac arrest in refractory epilepsy ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 86, no. 3, pp. 309-313 . https://doi.org/10.1136/jnnp-2014-307772 Journal of Neurology, Neurosurgery, and Psychiatry, vol. 86, no. 3, pp. 309-313 Journal of Neurology, Neurosurgery, and Psychiatry Journal of Neurology, Neurosurgery and Psychiatry, 86(3), 309-313 Journal of Neurology, Neurosurgery and Psychiatry, 86(3), 309-313. BMJ Publishing Group Lamberts, R J, Blom, M T, Novy, J, Belluzzo, M, Seldenrijk, A, Penninx, B W, Sander, J W, Tan, H L & Thijs, R D 2015, ' Increased prevalence of ECG markers for sudden cardiac arrest in refractory epilepsy ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 86, no. 3, pp. 309-313 . https://doi.org/10.1136/jnnp-2014-307772 |
| ISSN: | 0022-3050 |
| Popis: | Background and aim: People with epilepsy are at increased risk of sudden cardiac arrest (SCA) due to ECG-confirmed ventricular tachycardia/fibrillation, as seen in a community-based study. We aimed to determine whether ECG-risk markers of SCA are more prevalent in people with epilepsy. Methods: In a cross-sectional, retrospective study, we analysed the ECG recordings of 185 people with refractory epilepsy and 178 controls without epilepsy. Data on epilepsy characteristics, cardiac comorbidity, and drug use were collected, and general ECG variables (heart rate (HR), PQ and QRS intervals) assessed. We analysed ECGs for three markers of SCA risk: severe QTc prolongation (male >450 ms, female >470 ms), Brugada ECG pattern, and early repolarisation pattern (ERP). Multivariate regression models were used to analyse differences between groups, and to identify associated clinical and epilepsy-related characteristics. Results: People with epilepsy had higher HR (71 vs 62 bpm, p0.999). After adjustment for covariates, epilepsy remained associated with ERP (ORadj 2.4, 95% CI 1.1 to 5.5) and severe QTc prolongation (ORadj 9.9, 95% CI 1.1 to 1317.7). Conclusions: ERP and severe QTc prolongation appear to be more prevalent in people with refractory epilepsy. Future studies must determine whether this contributes to increased SCA risk in people with epilepsy. |
| Databáze: | OpenAIRE |
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