Traumatic brain injury activation of the adult subventricular zone neurogenic niche

Autor:	Chang, Eun Hyuk, Adorjan, Istvan, Mundim, Mayara V., Sun, Bin, Dizon, Maria L. V., Szele, Francis G.
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	adult neurogenesis nervous system General Neuroscience Stem Cells proliferation Regeneration Review Traumatic brain injury (TBI) lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Neuroscience lcsh:RC321-571
Zdroj:	Frontiers in Neuroscience, Vol 10 (2016) Frontiers in Neuroscience
DOI:	10.3389/fnins.2016.00332/full
Popis:	Traumatic brain injury (TBI) is common in both civilian and military life placing a large burden on survivors and society. However, with recognition of neural stem cells in adult mammals, including humans, came the possibility of harnessing these cells for repair of damaged brain tissue, previously thought to be a lost cause. In this review we focus on the adult subventricular zone (SVZ), an important neurogenic niche within the mature brain in which neural stem cells continue to reside. We review how the SVZ is perturbed following various animal traumatic brain injury models with regards to cell proliferation, emigration, survival and differentiation, and we review specific molecules involved in these processes. Together, this information suggests next steps in attempting to translate knowledge from animal models of TBI into human therapies for TBI.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f7bc17a2fd9ca0f7034c1968aed9419a http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00332/full Zobrazit plný text záznamu