Automatic Sleep Spindle Detection and Genetic Influence Estimation Using Continuous Wavelet Transform

Autor: Marek, Adamczyk, Lisa, Genzel, Martin, Dresler, Axel, Steiger, Elisabeth, Friess
Rok vydání: 2015
Předmět:
Zdroj: Frontiers in Human Neuroscience, 9
Frontiers in Human Neuroscience, Vol 9 (2015)
Adamczyk, M, Genzel, L, Dresler, M, Steiger, A & Friess, E 2015, ' Automatic Sleep Spindle Detection and Genetic Influence Estimation Using Continuous Wavelet Transform ', Frontiers in Human Neuroscience, vol. 9, pp. 624 . https://doi.org/10.3389/fnhum.2015.00624
FRONTIERS IN HUMAN NEUROSCIENCE
Frontiers in Human Neuroscience
ISSN: 1662-5161
DOI: 10.3389/fnhum.2015.00624
Popis: Contains fulltext : 151960.pdf (Publisher’s version ) (Open Access) Mounting evidence for the role of sleep spindles in neuroplasticity has led to an increased interest in these non-rapid eye movement (NREM) sleep oscillations. It has been hypothesized that fast and slow spindles might play a different role in memory processing. Here, we present a new sleep spindle detection algorithm utilizing a continuous wavelet transform (CWT) and individual adjustment of slow and fast spindle frequency ranges. Eighteen nap recordings of ten subjects were used for algorithm validation. Our method was compared with both a human scorer and a commercially available SIESTA spindle detector. For the validation set, mean agreement between our detector and human scorer measured during sleep stage 2 using kappa coefficient was 0.45, whereas mean agreement between our detector and SIESTA algorithm was 0.62. Our algorithm was also applied to sleep-related memory consolidation data previously analyzed with a SIESTA detector and confirmed previous findings of significant correlation between spindle density and declarative memory consolidation. We then applied our method to a study in monozygotic (MZ) and dizygotic (DZ) twins, examining the genetic component of slow and fast sleep spindle parameters. Our analysis revealed strong genetic influence on variance of all slow spindle parameters, weaker genetic effect on fast spindles, and no effects on fast spindle density and number during stage 2 sleep.
Databáze: OpenAIRE
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