Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease
| Autor: | Hasham, Muneer G., Baxan, Nicoleta, Stuckey, Daniel J., Branca, Jane, Perkins, Bryant, Dent, Oliver, Duffy, Ted, Hameed, Tolani S., Stella, Sarah E., Bellahcene, Mohammed, Schneider, Michael D., Harding, Sian E., Rosenthal, Nadia, Sattler, Susanne |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Cardiomyopathy
Dilated Male Toll-like receptor 7/8 Resiquimod Dilated cardiomyopathy lcsh:Medicine Autoimmunity Heart disease Adaptive Immunity lcsh:Pathology Animals Autoantibodies Inflammation Immunity Cellular Myocardium lcsh:R Imidazoles Genetic Variation Adoptive Transfer Myocarditis Disease Models Animal Toll-Like Receptor 7 Toll-Like Receptor 8 Heart Function Tests Mutation Female Lymph Nodes Spleen lcsh:RB1-214 Research Article Model |
| Zdroj: | Disease Models & Mechanisms Disease Models & Mechanisms, Vol 10, Iss 3, Pp 259-270 (2017) |
| ISSN: | 1754-8411 1754-8403 |
| Popis: | Systemic autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) show significant heart involvement and cardiovascular morbidity, which can be due to systemically increased levels of inflammation or direct autoreactivity targeting cardiac tissue. Despite high clinical relevance, cardiac damage secondary to systemic autoimmunity lacks inducible rodent models. Here, we characterise immune-mediated cardiac tissue damage in a new model of SLE induced by topical application of the Toll-like receptor 7/8 (TLR7/8) agonist Resiquimod. We observe a cardiac phenotype reminiscent of autoimmune-mediated dilated cardiomyopathy, and identify auto-antibodies as major contributors to cardiac tissue damage. Resiquimod-induced heart disease is a highly relevant mouse model for mechanistic and therapeutic studies aiming to protect the heart during autoimmunity. Summary: A novel mouse model of autoimmune-mediated heart damage to study the underlying mechanisms and test therapeutic options for systemic autoimmunity. |
| Databáze: | OpenAIRE |
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