Vascular biology of the biliary epithelium
| Autor: | Morell, Cm, Fabris, Luca, Strazzabosco, M. |
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| Přispěvatelé: | Morell, C, Fabris, L, Strazzabosco, M |
| Rok vydání: | 2012 |
| Předmět: |
Vascular Endothelial Growth Factor A
Bile Duct Diseases peribiliary plexu Epithelium Article Paracrine Communication Animals Humans biliary tree cholangiocytes Liver Diseases Alcoholic Platelet-Derived Growth Factor cholangiopathies liver Neovascularization Pathologic cholangiopathie Epithelial Cells PDGF VEGF Liver Regeneration Rats Autocrine Communication Bile Ducts Intrahepatic Liver Angiopoietins Signal Transduction |
| Zdroj: | Journal of gastroenterology and hepatology. 28 |
| ISSN: | 1440-1746 |
| Popis: | Cholangiocytes are involved in a variety of processes essential for liver pathophysiology. To meet their demanding metabolic and functional needs, bile ducts are nourished by their own arterial supply, the peribiliary plexus. This capillary network originates from the hepatic artery and is strictly arranged around the intrahepatic bile ducts. Biliary and vascular structures are linked by a close anatomic and functional association necessary for liver development, normal organ physiology, and liver repair. This strong association is finely regulated by a range of angiogenic signals, enabling the cross talk between cholangiocytes and the different vascular cell types. This review will briefly illustrate the "vascular" properties of cholangiocytes, their underlying molecular mechanisms and the relevant pathophysiological settings. |
| Databáze: | OpenAIRE |
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