Accumulation of Antigen-Driven Lymphoproliferations in Complement Receptor 2/CD21
| Autor: | Glauzy, Salomé, Boccitto, Marco, Bannock, Jason M., Delmotte, Fabien R., Saadoun, David, Cacoub, Patrice, Ice, John A., Sivils, Kathy L., James, Judith A., Wolin, Sandra L., Meffre, Eric |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
B-Lymphocytes Receptors Antigen B-Cell Enzyme-Linked Immunosorbent Assay Complement System Proteins Middle Aged Flow Cytometry Polymerase Chain Reaction Article Lymphoproliferative Disorders Sjogren's Syndrome Rheumatoid Factor Mutation Humans Immunoprecipitation Female Receptors Complement 3d Fluorescent Antibody Technique Indirect Aged Autoantibodies |
| Zdroj: | Arthritisrheumatology (Hoboken, N.J.). 70(2) |
| ISSN: | 2326-5205 |
| Popis: | Patients with Sjögren's syndrome (SS) are prone to develop malignant lymphomas, and a correlation has been established between the lymphoproliferations occurring in these disorders and the presence in patients' blood of an unusual B cell population that down-regulates complement receptor 2/CD21. This study was undertaken to identify the B cell compartment from which these lymphoproliferations emerge and determine the mechanisms that promote clonal B cell expansion in patients with SS.The reactivity of antibodies expressed by CD19+CD10-CD27-IgM+CD21Clonal expansions were identified in CD21Clonal lymphoproliferations in patients with SS preferentially accumulate in the autoreactive CD21 |
| Databáze: | OpenAIRE |
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