Can we Save the rectum by watchful waiting or TransAnal microsurgery following (chemo) Radiotherapy versus Total mesorectal excision for early REctal Cancer (STAR-TREC study)?: protocol for a multicentre, randomised feasibility study
| Autor: | Rombouts, A, Al-Najami, I, Abbott, N, Appelt, A, Baatrup, G, Bach, S, Bhangu, A, Garm Spindler, K, Gray, R, Handley, K, Kaur, M, Kerkhof, E, Kronborg, C, Magill, L, Marijnen, C, Nagtegaal, I, Nyvang, L, Peters, F, Pfeiffer, P, Punt, C, Quirke, P, Sebag-Montefiore, D, Teo, M, West, N, De Wilt, J |
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| Přispěvatelé: | CCA - Cancer Treatment and Quality of Life, Oncology, CCA -Cancer Center Amsterdam |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Microsurgery
Adenocarcinoma Chemoradiotherapy/methods Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] Protocol Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14] Humans Rectum/pathology rectal cancer chemoradiation Watchful Waiting radiotherapy Digestive System Surgical Procedures watchful waiting Adenocarcinoma/pathology Rectal Neoplasms Rectum Chemoradiotherapy Microsurgery/methods Europe Digestive System Surgical Procedures/methods Treatment Outcome Research Design TEM Feasibility Studies Regression Analysis Surgery Rectal Neoplasms/pathology Organ Sparing Treatments |
| Zdroj: | BMJ open, 7(12). BMJ Publishing Group BMJ Open, 7, 12, pp. e019474-e019474 BMJ Open BMJ Open, 7, e019474-e019474 Rombouts, A J M, Al-Najami, I, Abbott, N L, Appelt, A, Baatrup, G, Bach, S, Bhangu, A, Garm Spindler, K-L, Gray, R, Handley, K, Kaur, M, Kerkhof, E, Kronborg, C J, Magill, L, Marijnen, C A M, Nagtegaal, I D, Nyvang, L, Peters, F P, Pfeiffer, P, Punt, C, Quirke, P, Sebag-Montefiore, D, Teo, M, West, N, de Wilt, J H W & for STAR-TREC Collaborative Group 2017, ' Can we Save the rectum by watchful waiting or TransAnal microsurgery following (chemo) Radiotherapy versus Total mesorectal excision for early REctal Cancer (STAR-TREC study)? protocol for a multicentre, randomised feasibility study ', BMJ Open, vol. 7, no. 12, e019474 . https://doi.org/10.1136/bmjopen-2017-019474 Rombouts, A J M, Al-Najami, I, Abbott, N L, Appelt, A, Baatrup, G, Bach, S, Bhangu, A, Garm Spindler, K-L, Gray, R, Handley, K, Kaur, M, Kerkhof, E, Kronborg, C J, Magill, L, Marijnen, C A M, Nagtegaal, I D, Nyvang, L, Peters, F P, Pfeiffer, P, Punt, C, Quirke, P, Sebag-Montefiore, D, Teo, M, West, N, de Wilt, J H W & for STAR-TREC Collaborative Group 2017, ' Can we Save the rectum by watchful waiting or TransAnal microsurgery following (chemo) Radiotherapy versus Total mesorectal excision for early REctal Cancer (STAR-TREC study)?: protocol for a multicentre, randomised feasibility study ', BMJ Open, vol. 7, no. 12, pp. e019474 . https://doi.org/10.1136/bmjopen-2017-019474 |
| ISSN: | 2044-6055 |
| DOI: | 10.1136/bmjopen-2017-019474 |
| Popis: | Contains fulltext : 181874.pdf (Publisher’s version ) (Open Access) INTRODUCTION: Total mesorectal excision (TME) is the highly effective standard treatment for rectal cancer but is associated with significant morbidity and may be overtreatment for low-risk cancers. This study is designed to determine the feasibility of international recruitment in a study comparing organ-saving approaches versus standard TME surgery. METHODS AND ANALYSIS: STAR-TREC trial is a multicentre international randomised, three-arm parallel, phase II feasibility study in patients with biopsy-proven adenocarcinoma of the rectum. The trial is coordinated from Birmingham, UK with national hubs in Radboudumc (the Netherlands) and Odense University Hospital Svendborg UMC (Denmark). Patients with rectal cancer, staged by CT and MRI as |
| Databáze: | OpenAIRE |
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