The association of CD36 variants with polypoidal choroidal vasculopathy compared to typical neovascular age-related macular degeneration

Autor:	Bessho, H., Honda, S., Naoshi Kondo, Kusuhara, S., Tsukahara, Y., Negi, A.
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	Aged 80 and over CD36 Antigens Male Middle Aged complex mixtures Polymorphism Single Nucleotide Choroidal Neovascularization Macular Degeneration Haplotypes Case-Control Studies Humans Female Genetic Predisposition to Disease Genetic Association Studies Research Article Aged
Zdroj:	Molecular Vision Scopus-Elsevier
ISSN:	1090-0535
Popis:	Purpose To clarify the association of cluster of differentiation 36 (CD36) variants with polypoidal choroidal vasculopathy (PCV) and compare them with those in typical neovascular age-related macular degeneration (tAMD). Methods We included 349 Japanese AMD patients (210 PCV, 139 tAMD) and 198 age-matched controls. Four tag single-nucleotide polymorphisms (SNPs)—rs10499862, rs3173798, rs3211883, and rs3173800—in the CD36 region were genotyped using the TaqMan assay. Allelic and genotypic frequencies of the SNPs were tested. Results Although none of the SNPs tested were associated with PCV, the allelic frequencies of rs3173798 and rs3173800 were significantly different between PCV and tAMD patients. Genotype association analysis demonstrated different associations of these two SNPs between PCV and tAMD in the genotype model. Haplotype analysis revealed that the association of the major haplotype (T-T-T-T) at four selected SNPs in CD36 differed significantly between PCV and tAMD patients. Conclusions The CD36 region may be associated with the difference in genetic susceptibility for PCV and tAMD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f1e44e6c8006c049a67c5389ae3b0182 http://europepmc.org/articles/PMC3265175 Zobrazit plný text záznamu