Incremental value of HBcrAg to classify 1582 HBeAg-negative individuals in chronic infection without liver disease or hepatitis

Autor: Brunetto, MR, Carey, I, Maasoumy, B, Marcos-Fosch, C, Boonstra, Andre, Caviglia, GP, Loglio, A, Cavallone, D, Scholtes, C, Ricco, G, Smedile, A, Riveiro-Barciela, M, van Bommel, F, Baltissen - van der Eijk, Annemiek, Zoulim, F, Berg, Thomas, Cornberg, M, Lampertico, P, Agarwal, K, Buti, M
Přispěvatelé: Gastroenterology & Hepatology
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Alimentary Pharmacology & Therapeutics, 53(6), 733-744. Wiley-Blackwell Publishing Ltd
ISSN: 0269-2813
Popis: Background: An accurate, single-point differential diagnosis between HBeAg-negative infection (ENI) and chronic hepatitis B (CHB) is an unmet need. Aims: To assess the diagnostic value of the new hepatitis B core-related antigen (HBcrAg) assay. Methods: A retrospective anonymised data analysis was performed in a multicentre European (nine centres and six countries) cohort of 1582 consecutive HBsAg-positive/HBeAg-negative subjects classified according to EASL guidelines as: 550-CHB, 710-ENI and 322-GZ (grey-zone, HBV-DNA
Databáze: OpenAIRE