Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model
| Autor: | M, Hüttenrauch, A, Brauß, A, Kurdakova, H, Borgers, F, Klinker, D, Liebetanz, G, Salinas-Riester, J, Wiltfang, H W, Klafki, O, Wirths |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Neurons
Memory Disorders physiopathology [Neurodegenerative Diseases] Neurodegenerative Diseases complications [Alzheimer Disease] Mice Transgenic physiology [Neurons] Real-Time Polymerase Chain Reaction Hippocampus physiopathology [Alzheimer Disease] Disease Models Animal Mice Alzheimer Disease Physical Conditioning Animal physiopathology [Hippocampus] complications [Neurodegenerative Diseases] Animals physiopathology [Memory Disorders] Original Article hippocampal neurodegeneration rescues memory deficits Alzheimer disease ddc:610 complications [Memory Disorders] |
| Zdroj: | Translational Psychiatry 6(5), e800-e800 (2016). doi:10.1038/tp.2016.65 Translational Psychiatry |
| DOI: | 10.1038/tp.2016.65 |
| Popis: | The evidence for a protective role of physical activity on the risk and progression of Alzheimer's disease (AD) has been growing in the last years. Here we studied the influence of a prolonged physical and cognitive stimulation on neurodegeneration, with special emphasis on hippocampal neuron loss and associated behavioral impairment in the Tg4-42 mouse model of AD. Tg4-42 mice overexpress Aβ4-42 without any mutations, and develop an age-dependent hippocampal neuron loss associated with a severe memory decline. We demonstrate that long-term voluntary exercise diminishes CA1 neuron loss and completely rescues spatial memory deficits in different experimental settings. This was accompanied by changes in the gene expression profile of Tg4-42 mice. Deep sequencing analysis revealed an upregulation of chaperones involved in endoplasmatic reticulum protein processing, which might be intimately linked to the beneficial effects seen upon long-term exercise. We believe that we provide evidence for the first time that enhanced physical activity counteracts neuron loss and behavioral deficits in a transgenic AD mouse model. The present findings underscore the relevance of increased physical activity as a potential strategy in the prevention of dementia. Open-Access Publikationsfonds 2016 Open-Access-Publikationsfonds 2016 peerReviewed |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|