Synthesis and cytotoxicity evaluation of some new 6-nitro derivatives of thiazole-containing 4-(3H)-quinazolinone

Autor:	Hosseinzadeh, Leila, Aliabadi, Alireza, Kalantari, Masoud, Mostafavi, Abolfazl, Khajouei, Marzieh Rahmani
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	RS1-441 Pharmacy and materia medica Quinazolinone Thiazole Cytotoxicity Original Article
Zdroj:	Research in Pharmaceutical Sciences, Vol 11, Iss 3, Pp 210-218 (2016) Research in Pharmaceutical Sciences
ISSN:	1735-9414 1735-5362
Popis:	Quinazolinones are a group of fused heterocyclic compounds which have valuable biological properties including cytotoxic, antibacterial and antifungal activities. Thiazole group-containing compounds have been also reported to have a wide range of biological activities such as antitumor, anti-inflammatory, analgesic and antibacterial effects. Due to valuable cytotoxic effects of both thiazole groups and quinazoline derivatives, in this study a series of quinazolinone-thiazole hybrids were synthesized and evaluated for their cytotoxic effects on three cell lines including MCF-7, HT-29, and PC-3. Among tested compounds (quinazolinones and three intermediates), k5 and k6 showed highest cytotoxic activities against PC3 cell line. K6 and C were most active compounds against MCF7 and K6 showed best cytotoxicity on HT-29 cell line.
Databáze:	OpenAIRE
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