Mitochondrial and redox dysfunction in post-menopause as risk factor of neurodegenerative disease: a pilot study testing the role of a validated Japanese functional food
| Autor: | Marotta F., Marcellino M., Catanzaro R., Campiotti A., Lorenzetti A., Cervi J., Barbagallo M. |
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| Přispěvatelé: | Marotta, F, Marcellino, M, Catanzaro, R, Campiotti, A, Lorenzetti, A, Cervi, J, Barbagallo, M, Marotta F., Marcellino M., Catanzaro R., Campiotti A., Lorenzetti A., Cervi J., Barbagallo M. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
MDA
menopause Pilot Projects Antioxidants Electron Transport Complex IV FPP-ORI Japan Functional Food Risk Factors Malondialdehyde BDNF COX activity GPx SOD1 mitochondria redox dysfunction Humans Brain-Derived Neurotrophic Factor Neurodegenerative Diseases Postmenopause Oxidative Stress Leukocytes Mononuclear redox dysfunctionc Female Oxidation-Reduction |
| Popis: | During the menopause women may experience increased oxidative stress and decreased antioxidant capacity and, together with the decline of neurosteroids, this represents a risk factor for Alzheimer's disease. The aim of the present study was to test a functional food (FPP-ORI, Osato Research Institute, Gifu, Japan) on redox and mitochondrial efficiency in post-menopausal women. The study population consisting of 69 untreated post-menopausal women were given supplements as follows: Group A was given a multivitamin (MV) 1c 2 times a day, and group B was given FPP 4.5 g 2 times a day. Group C consisted of 23 fertile premenopausal women as the control group. The tests carried out on entry, and at 3 and 6 months were erythrocyte redox parameters, plasma oxidated proteins, brain-derived neurotrophic factor (BDNF) and peripheral blood mononuclear cell (PBMC) mitochondria cytochrome c oxidase Vmax activity. Menopausal women showed an increased malondialdehyde (MDA) (p= 26 subgroup (p= 26" subgroup (p |
| Databáze: | OpenAIRE |
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