The VEGF gene polymorphism in glioblastoma may be a new prognostic marker of overall survival

Autor:	Djan, I., Lucic, S., Bjelan, M., Vuckovic, N., Vucinic, N., ALESSIO GIUSEPPE MORGANTI, Djan, M., Lucic, M.
Přispěvatelé:	Djan, Igor, Lucic, Silvija, Bjelan, Mladen, Vuckovic, Nada, Vucinic, Natasa, Morganti, Alessio Giuseppe, Djan, Mihajla, Lucic, Milos
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Male Vascular Endothelial Growth Factor A Genotype Brain Neoplasms Prognosi Chemoradiotherapy Middle Aged Prognosis Polymorphism Single Nucleotide nervous system diseases Follow-Up Studie Brain Neoplasm Survival Rate Humans Female Glioblastoma neoplasms Follow-Up Studies Aged Human
Zdroj:	Scopus-Elsevier
Popis:	Glioblastoma (GBM) is the most aggressive primary brain tumor. Vascular endothelial growth factor (VEGF) gene polymorphisms and overexpression are involved in high-grade malignant gliomas. The aim of this study was to assess the distribution of +405CG VEGF gene polymorphism in patients diagnosed by glioblastoma and to test its association with the overall survival (OS).Patients diagnosed for glioblastoma were randomly selected, and follow-up was conducted for a minimum of 36 months. Tissue paraffin embedded GBM samples were subjected for the VEGF polymorphism detection. The associations of the observed genotypes and clinical data were evaluated.The most frequent single nucleotide polymorphism (SNP) variant was G (72.58%). The GG genotype was proved to have statistically significant longer OS and patient status (alive/dead) compared to CC and CG genotypes (p=0.022 and 0.005, respectively).Our results indicate that +405CG VEGF gene polymorphism may be used as prognostic genetic marker of OS in GBM patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::edec89d7e89d717611f1dae765a4ae13 http://hdl.handle.net/11585/795891 Zobrazit plný text záznamu