Prognostic factors in a large multi-institutional series of papillary renal cell carcinoma
| Autor: | Zucchi, A, Novara, G, Costantini, E, Antonelli, A, Carini, M, Carmignani, G, Cosciani Cunico, S, Fontana, Dario, Longo, N, Martignoni, G, Minervini, A, Mirone, V, Porena, M, Roscigno, M, Schiavina, R, Simeone, C, Simonato, A, Siracusano, S, Terrone, Carlo, Ficarra, V. |
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| Přispěvatelé: | ZUCCHI A, NOVARA G, COSTANTINI E, ANTONELLI A, CARINI M, CARMIGNANI G, COSCIANI CUNICO S, FONTANA D, LONGO N, MARTIGNONI G, MINERVINI A, MIRONE V, PORENA M, ROSCIGNO M, SCHIAVINA R., SIMEONE C, SIMONATO A, SIRACUSANO S, TERRONE C, FICARRA V., Zucchi, A, Novara, G, Costantini, E, Antonelli, A, Carini, M, Carmignani, G, Cosciani Cunico, S, Fontana, D, Longo, N, Martignoni, G, Minervini, A, Mirone, V, Porena, M, Roscigno, M, Schiavina, R, Simeone, C, Simonato, A, Siracusano, Salvatore, Terrone, C, Ficarra, V., Zucchi, Alessandro, Novara, Giacomo, Costantini, Elisabetta, Antonelli, Alessandro, Carini, Marco, Carmignani, Giorgio, Cosciani Cunico, Sergio, Fontana, Dario, Longo, Nicola, Martignoni, Guido, Minervini, Andrea, Mirone, Vincenzo, Porena, Massimo, Roscigno, Marco, Schiavina, Riccardo, Simeone, Claudio, Simonato, Alchiede, Terrone, Carlo, Ficarra, Vincenzo, A., Zucchi, G., Novara, E., Costantini, A., Antonelli, M., Carini, G., Carmignani, S. C., Cunico, D., Fontana, G., Martignoni, A., Minervini, M., Porena, M., Roscigno, R., Schiavina, C., Simeone, A., Simonato, S., Siracusano, C., Terrone, V., Ficarra |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
renal cell carcinoma Time Factors Papillary renal cell carcinoma Prognostic factors Prognosi FEATURES kidney cancer papillary papillary adenocarcinoma prognostic factors papillary renal cell carcinoma Nephrectomy CLASSIFICATION Follow-Up Studie cancer-specific survival Risk Factors Retrospective Studie Cause of Death Prevalence Humans recurrence-free survival prognostic factor Carcinoma Renal Cell TYPE-1 Proportional Hazards Models Retrospective Studies Neoplasm Staging Academic Medical Centers Risk Factor Kidney Neoplasm Middle Aged Prognosis TUMORS Kidney Neoplasms HISTOLOGIC SUBTYPES Prognostic factors in a large multi-institutional series of papillary renal cell carcinoma Survival Rate Academic Medical Center Italy SURVIVAL Proportional Hazards Model Female Follow-Up Studies Human |
| Popis: | OBJECTIVES To investigate cancer-related outcomes and prognostic factors of papillary renal cell carcinoma (pRCC) in a large multicentre data set. Oncological outcome and prognostic factors of pRCC have been limitedly evaluated in comparison with the most common RCC subtype, clear cell RCC. PATIENTS AND METHODS From a multicentre retrospective database, including 5463 patients who were surgically treated for RCC at 16 Italian academic centres between 1995 and 2007, 577 patients with pRCC were identified. Univariable and multivariable Cox regression models were performed to identify prognostic factors predictive of recurrence-free survival (RFS) and cancer-specific survival (CSS) after surgery. RESULTS At a median (interquartile range) follow-up of 39.2 (21.7-72) months, 81 (14%) patients had experienced disease progression and 63 (11%) patients had died from disease; the 5-year RFS estimate was 85.5%. In multivariable analysis, pathological N stage (pooled P < 0.001), M stage (hazard ratio, 2.9; P = 0.007) and Fuhrman nuclear grade (pooled P = 0.039) were all independent predictors of RFS; the 5-year CSS estimate was 87.9%. In Cox multivariable analysis, an independent predictive role was reconfirmed for mode of presentation (pooled P = 0.038), pathological N stage (pooled P < 0.001), M stage (hazard ratio, 2.4; P = 0.049) and Fuhrman nuclear grade (pooled P = 0.037). CONCLUSIONS Patients with pRCC have a low risk of tumour recurrence and cancer-related death after surgery. Fuhrman nuclear grade was found to be a stronger predictor of both RFS and CSS, whereas only a non-statistically significant trend was found for the 2009 pathological T stage. |
| Databáze: | OpenAIRE |
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