| Autor: |
Raul R Gainetdinov, Ii, Miroshnichenko, Vs, Kudrin, Mb, Bogdanov, Vm, Pogorelov, Ea, Budygin, Gi, Kovalev, Ks, Raevskiĭ |
| Předmět: |
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| Zdroj: |
Europe PubMed Central |
| Popis: |
The effects of cis- and trans-isomers of atypical neuroleptic carbidine on the synthesis of dopamine and its autoreceptor regulation in the striatum and nucleus accumbens of rats were examined by blocking decarboxylase of L-aromatic amino acids and interrupting the nerve impulse flow in the dopaminergic neurons. The striatal release and metabolism of dopamine were studied in vitro by employing K(+)-stimulated efflux from isolated striata and in vivo by the microdialysis in freely moving rats. Carbidine trans-isomer, unlike its cis-isomer, was shown to enhance the biosynthesis of dopamine via blockade of presynaptic autoreceptors presumably located on the dopaminergic terminals. The trans-isomer was found to be much more potent by affecting the neurochemical parameters of dopaminergic neurotransmission, which are essential for the drug to produce its antipsychotic effect. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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