New reciprocal translocation t(5;10)(q33;q22) associated with atypical chronic myeloid leukemia

Autor:	Siena, S., Sammarelli, G., Grimoldi, M. G., Schiavo, R., Nozza, A., Roncalli, M., Mecucci, C., Santoro, A., Carmelo Carlo-Stella
Předmět:	Male Chromosomes Human Pair 10 Karyotyping Leukemia Myelogenous Chronic BCR-ABL Positive Chromosomes Human Pair 5 Humans Middle Aged Translocation Genetic
Zdroj:	Scopus-Elsevier IRIS Humanitas University Europe PubMed Central
Popis:	We report a new chromosomal reciprocal translocation t(5;10)(q33;q22) in a 49-year-old man with atypical chronic myeloid leukemia (a-CML) and history of occupational exposure to petroleum products including benzene and other hydrocarbons. The t(5;10) (q33;q22) was found in 94% and 84% of metaphases in peripheral blood and bone marrow cells, respectively. Cytogenetic analysis of single colonies derived from granulocyte-macrophage (CFU-GM), and erythroid (BFU-E) hematopoietic progenitors showed that 88% and 40% of CFU-GM and BFU-E, respectively, had the t(5;10)(q33;q22). In contrast, peripheral blood T-lymphocytes, and cutaneous fibroblasts had normal 46,XY karyotype. Molecular analysis of the t(5;10)(q33;q22) translocation breakpoint is currently underway in order to identify genes located in this region which might provide insights into the pathogenesis of atypical myeloproliferative disorders.
Databáze:	OpenAIRE
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