Physical activity and risk of prostate and bladder cancer in China: The South and East China case-control study on prostate and bladder cancer
| Autor: | Reulen, Raoul C., de Vogel, Stefan, Zhong, Weide, Zhong, Zhaohui, Xie, Li-Ping, Hu, Zhiquan, Deng, Yilan, Yang, Kai, Liang, Yuxiang, Zeng, Xing, Wong, Yong Chuan, Tam, Po-Chor, Hemelt, Marjolein, Zeegers, Maurice P. |
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| Přispěvatelé: | RS: CAPHRI - R5 - Optimising Patient Care, Complexe Genetica |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
lcsh:Medicine Geographical Locations Mathematical and Statistical Techniques Risk Factors Medicine and Health Sciences Public and Occupational Health lcsh:Science Aged 80 and over Prostate Cancer Prostate Diseases MEN Middle Aged Bladder Cancer Oncology Research Design Physical Sciences Female Anatomy Statistics (Mathematics) Research Article China Asia CARCINOMA Urology Research and Analysis Methods LUNG-CANCER Exocrine Glands Diagnostic Medicine Cancer Detection and Diagnosis Humans COHORT VALIDITY Statistical Methods METAANALYSIS Aged lcsh:R Prostatic Neoplasms Cancers and Neoplasms Biology and Life Sciences Physical Activity Genitourinary Tract Tumors Urinary Bladder Neoplasms TAIWAN Case-Control Studies People and Places Prostate Gland lcsh:Q Mathematics Meta-Analysis |
| Zdroj: | PLoS ONE, Vol 12, Iss 6, p e0178613 (2017) PLoS ONE PLOS ONE, 12(6):e0178613. Public Library of Science |
| ISSN: | 1932-6203 |
| Popis: | Background Recent meta-analyses have suggested a modest protective effect of high levels of physical activity on developing both prostate and bladder cancer, but significant heterogeneity between studies included in these meta-analyses existed. To our knowledge, few Chinese studies investigated the association between physical activity and prostate cancer and none between physical activity and bladder cancer. Given the inconsistencies between previous studies and because studies on the relation between physical activity and prostate and bladder cancer in China are scarce, it remains elusive whether there is a relationship between physical activity and prostate and bladder cancer within the Chinese population. Methods We investigated the association between physical activity and risk of developing prostate and bladder cancer within a hospital-based case-control study in the East and South of China among 260 and 438 incident prostate and bladder cancer cases, respectively, and 427 controls. A questionnaire was administered to measure physical activity as metabolic equivalents (METs). Random effects logistic regression was used to calculate odds ratios (ORs) of prostate and bladder cancer for different levels of physical activity and for the specific activities of walking and cycling. Results Increasing overall physical activity was associated with a significant reduction in prostate cancer risk (P-trend = 0.04) with the highest activity tertile level showing a nearly 50% reduction in prostate cancer risk (OR = 0.53, 95% CI: 0.28-0.98). Overall physical activity was not significantly associated with risk of bladder cancer (Ptrend = 0.61), neither were vigorous (P-trend = 0.60) or moderate levels of physical activity (P-trend = 0.21). Walking and cycling were not significantly associated with either prostate (P-trend > = 0.62) or bladder cancer risk (P-trend > = 0.25). Conclusions The findings of this largest ever case-control study in China investigating the relationship between physical activity and prostate and bladder cancer suggest that overall physical activity is associated with a decreased risk of prostate cancer, but not with bladder cancer. |
| Databáze: | OpenAIRE |
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