Anti-plasmodial and anti-inflammatory activities of cyclotide-rich extract and fraction of Oldenlandia affinis (R. & S.) D.C. (Rubiaceae)

Autor: Nworu, Chukwuemeka Sylvester, Ejikeme, Tochukwu Ifenyinwa, Ezike, Adaobi Chioma, Ndu, Okechukwu, Akunne, Theophine Chinwuba, Onyeto, Collins Azubuike, Okpalanduka, Paul, Akah, Peter Achunike
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: African Health Sciences
African Health Sciences; Vol 17, No 3 (2017); 827-843
ISSN: 1729-0503
1680-6905
Popis: Background: Oldenlandia affinis, commonly called ‘kalata-kalata’, a versatile plant used locally to treat malaria fever in some parts of sub-Saharan Africa was investigated for anti-plasmodial and anti-inflammatory activities.Objective: The study was designed to evaluate the antiplasmodial as well as anti-inflammatory activities of whole extract and cyclotide-rich fraction of Oldenlandia affinis.Method: The dichloromethane-methanol extract (ODE) of the plant, O. affinis was investigated for suppressive and curative antiplasmodial activities against Plasmodium berghei in mice. ODE and the cyclotide-rich fraction (CRF) was investigated for chronic and acute anti-inflammatory activities in rat models of inflammation. Inhibition of pro-inflammatory mediators was studied in RAW264.7 macrophages.Results: ODE exhibited significant (p
Databáze: OpenAIRE