Anti-plasmodial and anti-inflammatory activities of cyclotide-rich extract and fraction of Oldenlandia affinis (R. & S.) D.C. (Rubiaceae)
Autor: | Nworu, Chukwuemeka Sylvester, Ejikeme, Tochukwu Ifenyinwa, Ezike, Adaobi Chioma, Ndu, Okechukwu, Akunne, Theophine Chinwuba, Onyeto, Collins Azubuike, Okpalanduka, Paul, Akah, Peter Achunike |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Plasmodium berghei
Plant Extracts Tumor Necrosis Factor-alpha Oldenlandia affinis Anti-Inflammatory Agents Cyclotides Articles Reactive oxygen/nitrogen species pro-inflammatory mediators Malaria Rats Oldenlandia Antimalarials Disease Models Animal Inhibitory Concentration 50 Mice Oldenlandia affinis Reactive oxygen/nitrogen species Plasmodium berghei pro-inflammatory mediators parasitemia parasitic diseases Animals parasitemia |
Zdroj: | African Health Sciences African Health Sciences; Vol 17, No 3 (2017); 827-843 |
ISSN: | 1729-0503 1680-6905 |
Popis: | Background: Oldenlandia affinis, commonly called ‘kalata-kalata’, a versatile plant used locally to treat malaria fever in some parts of sub-Saharan Africa was investigated for anti-plasmodial and anti-inflammatory activities.Objective: The study was designed to evaluate the antiplasmodial as well as anti-inflammatory activities of whole extract and cyclotide-rich fraction of Oldenlandia affinis.Method: The dichloromethane-methanol extract (ODE) of the plant, O. affinis was investigated for suppressive and curative antiplasmodial activities against Plasmodium berghei in mice. ODE and the cyclotide-rich fraction (CRF) was investigated for chronic and acute anti-inflammatory activities in rat models of inflammation. Inhibition of pro-inflammatory mediators was studied in RAW264.7 macrophages.Results: ODE exhibited significant (p |
Databáze: | OpenAIRE |
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