Increased Bone Turnover Markers after Renal Transplantation
| Autor: | Gršković, A., Ćelić, T., Fučkar, D., Dean Markić, Trošelj, M., Bobinac, D. |
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| Předmět: |
Adult
Chronic Kidney Disease-Mineral and Bone Disorder Male musculoskeletal diseases Osteoblasts chronic renal failure renal transplantation bone markers Osteoclasts Recovery of Function Middle Aged Kidney Transplantation chronic renal failure renal transplantation bone markers BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Urology Humans Kidney Failure Chronic Female Bone Remodeling BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Urologija Biomarkers Aged |
| Zdroj: | ResearcherID Collegium antropologicum Volume 34 supplement 2 Issue 2 Scopus-Elsevier |
| ISSN: | 0350-6134 1848-9486 |
| Popis: | Bone remodeling is a process that occurs continuously in a seemingly inactive tissue like bone. Because of decreased vitamin D synthesis, phosphorus retention and decreased calcium blood concentration, patients with chronic renal failure (CRF) develop secondary hyperparathyroidism1–5. Elevated PTH levels shifts balance between osteoblast and osteoclast activity in favor of osteoclast activity and, therefore, bone resorption. Bone metabolic disorder that affects patients with CRF is called renal osteodystrophy (ROD)1–5. We presume that renal transplantation reverses bone metabolism disorder and our goal was to establish whether osteoblast and osteoclast activity returns to the levels of healthy individuals. |
| Databáze: | OpenAIRE |
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