Delayed 24 hours Nomega-nitro-L-arginine methyl ester injection induces pharmacological cardioprotection against reperfusion injury
| Autor: | Davani S, CATHERINE VERGELY, Royer B, Bouhaddi M, Reyssie H, Rochette L, Jp, Kantelip |
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| Přispěvatelé: | Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( EA 3920) (PCVP / CARDIO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( PCVP / CARDIO ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ) -Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Adenosine
Time Factors MESH : Cardiotonic Agents Myocardial Ischemia MESH : Myocardial Ischemia Blood Pressure Ventricular Function Left MESH: Ventricular Function Left MESH: Theophylline MESH : Arginine MESH : Troponin I MESH: Animals Enzyme Inhibitors MESH : Rats MESH : Nitrites MESH: Nitrites MESH: Arginine MESH : Regional Blood Flow MESH : Nitrates MESH: Blood Pressure MESH: Myocardial Reperfusion Injury Perfusion MESH : Perfusion MESH: Nitrates MESH: Enzyme Inhibitors MESH: Myocardial Ischemia MESH: Nitric Oxide Synthase MESH: Perfusion MESH : Time Factors MESH : Ventricular Function Left MESH : Adenosine MESH: Troponin I Cardiotonic Agents MESH: Rats MESH : Myocardial Reperfusion Injury Myocardial Reperfusion Injury Arginine Theophylline [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology MESH : Theophylline MESH : Blood Pressure Animals Nitrites MESH : Enzyme Inhibitors Nitrates Troponin I MESH: Time Factors MESH : Nitric Oxide Synthase MESH: Cardiotonic Agents MESH: Adenosine MESH : Disease Models Animal Rats Disease Models Animal Regional Blood Flow MESH: Regional Blood Flow MESH : Animals Nitric Oxide Synthase MESH: Disease Models Animal [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Cellular and Molecular Biology Cellular and Molecular Biology, R. Wegmann, 2006, 52 Suppl, pp.OL868-73 Cellular and Molecular Biology, OMICS International, 2006, 52 Suppl, pp.OL868-73 Europe PubMed Central |
| ISSN: | 0145-5680 1165-158X |
| Popis: | International audience; Previous studies indicate that adenosine supplementation or nitric oxide synthase (NOS) inhibition during reperfusion exert protective effects against myocardial ischemia-reperfusion (I/R) injury. We wanted to test the hypothesis that NOS inhibition before I/R also protects the myocardium against further injury and aimed to determine the involvement of adenosine receptors in a perfused rat heart model. Rats were injected with 10 mg/kg of L-NAME (N(omega)-nitro-L-arginine methyl ester) or L-NAME + SPT (8-(p-sulfophenyl)-theophylline)--an adenosine antagonist - at 2 x 25 mg/kg or with a saline buffer, 24 hrs prior to heart excision. The hearts, perfused retrogradely were subjected to 60 min of global ischemia followed by 120 min reperfusion. L-NAME decreased NOx (nitrite and nitrate) production (16.2 +/- 3.2 vs. 7.0 +/- 1.8 micromol/L; P |
| Databáze: | OpenAIRE |
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