[Study of cellular immunology in malignant and benign monoclonal gammapathies]

Autor: Gasparotto, Giuseppe, Semenzato, GIANPIETRO CARLO, Tosato, F, Cazzaro, G, Amadori, Giuseppe
Jazyk: francouzština
Rok vydání: 1976
Předmět:
Zdroj: Schweizerische medizinische Wochenschrift. 106(50)
ISSN: 0036-7672
Popis: In 25 cases of myeloma and 15 cases of benign paraproteinemia the functional situation of circulating lymphocytes was studied. The technique used was the incorporation of 3H-thymidine after PHA stimulation. E rosette formation and immunoglobulin bearing cells were evaluated. A reduction of 3H-thymidine incorporation in the blastic cells was seen in the patients with myeloma (the difference was statistically significant: p less than 0.001). In benign monoclonal gammopathies the reduction was moderate and was not statistically significant. The different blastic response in vitro in the two group of patients tested confirms that the respective immunocompetent systems clearly differ.
Databáze: OpenAIRE