Neurotrophins and their receptors in human lingual tonsil: An immunohistochemical analysis

Autor: Artico, M, Bronzetti, E, Felici, L, Alicino, V, Ionta, B, Bronzetti, B, Magliulo, G, Grande, C, Zamai, L, Pasquantonio, G, De Vincentiis, M
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Cancer Research
protein p75
human lingual tonsil
receptors
Receptors
Nerve Growth Factor
cellular immunity
macrophage
lymphocyte
brain derived neurotrophic factor
brain derived neurotrophic factor receptor
nerve growth factor
neurotrophin
neurotrophin 3
neurotrophin 3 receptor
neurotrophin 4
neurotrophin receptor
protein tyrosine kinase A
nerve growth factor receptor
article
controlled study
human
human cell
human tissue
immunohistochemistry
innervation
nervous system function
priority journal
protein expression
tongue
tonsillitis
adenoid
biosynthesis
metabolism
vascular endothelium
Adenoids
Endothelium
Vascular
Humans
Immunohistochemistry
Lymphocytes
Macrophages
Nerve Growth Factors
neurotrophins
Settore MED/28 - Malattie Odontostomatologiche
Vascular
Human lingual tonsil
Neurotrophins
Receptors
Oncology
Endothelium
Popis: Lymphoid organs are supplied by many nerve endings associated with different kinds of cells and macrophages. The role of this innervation on the release of locally active molecules is still unclear. Lingual tonsils belong to Waldeyer's Ring, in close association with palatine tonsils and nasopharyngeal (adenoids) tonsils, thus constituting part of NALT (nasal-associated lymphoid tissue) together with the tubal tonsils and lateral pharyngeal bands. In this study, we focused our attention on the expression of some neurotrophins (NTs) and their high- and low-affinity receptors in human lingual tonsils. Light immunohistochemistry showed that human tonsillar samples were generally positive for all the NTs investigated (NGF, BDNF, NT-3, NT-4) and their receptors (TrKA, TrKB, TrKC and p75) with some different expression levels. NGF and TrKC were strongly expressed in macrophages, but weakly in lymphocytes. However, BDNF and TrKB was highly expressed in lymphocytes and weaker in macrophages. The low-affinity receptor for NGF, p75, was mainly moderately expressed in the analysed samples. These results suggest the presence of a pattern of neurotrophin innervation in the human lingual tonsil which may play a role in sustaining inflammatory conditions and in modulating a close interaction between the nervous system and the different immune cellular subtypes.
Databáze: OpenAIRE
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