Hedonic sensitivity to natural rewards is affected by prenatal stress in a sex-dependent manner

Autor: Reynaert, M-L. (Marie-Line), Marrocco, J. (Jordan), Mairesse, J. (Jérôme), Lionetto, L. (Luana), Simmaco, M. (Maurizio), Deruyter, L. (Lucie), Allorge, D. (Delphine), Moles, A. (Anna), Pittaluga, A. (Anna), Maccari, S. (Stefania), MORLEY-FLETCHER, S. (Sara), Van Camp, G. (Gilles), Nicoletti, F. (Ferdinando)
Přispěvatelé: Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Istituto Neurologico Mediterraneo (NEUROMED I.R.C.C.S.), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA)-University of Naples Federico II = Università degli studi di Napoli Federico II, Centro Neurolesi Bonino Pulejo Messina (IRCCS Messina), Azienda Ospedaliera Sant'Andrea [Roma], Impact de l'environnement chimique sur la santé humaine - ULR 4483 (IMPECS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Università degli studi di Genova = University of Genoa (UniGe), Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), CHU Lille, CNRS, Université de Lille, Institut Pasteur de Lille, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF], Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.], Centro Neurolesi Bonino Pulejo Messina [IRCCS Messina], 171461|||Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS], Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576, IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Addiction Biology
Addiction Biology, 2016, Addiction Biology, 21 (6), pp.1072-1085. ⟨10.1111/adb.12270⟩
ISSN: 1355-6215
1369-1600
Popis: International audience; Palatable food is a strong activator of the reward circuitry and may cause addictive behavior leading to eating disorders. How early life events and sex interact in shaping hedonic sensitivity to palatable food is largely unknown. We used prenatally restraint stressed (PRS) rats, which show abnormalities in the reward system and anxious/depressive-like behavior. Some of the hallmarks of PRS rats are known to be sex-dependent. We report that PRS enhanced and reduced milk chocolate-induced conditioned place preference in males and females, respectively. Male PRS rats also show increases in plasma dihydrotestosterone (DHT) levels and dopamine (DA) levels in the nucleus accumbens (NAc), and reductions in 5-hydroxytryptamine (5-HT) levels in the NAc and prefrontal cortex (PFC). In male rats, systemic treatment with the DHT-lowering drug finasteride reduced both milk chocolate preference and NAc DA levels. Female PRS rats showed lower plasma estradiol (E2) levels and lower DA levels in the NAc, and 5-HT levels in the NAc and PFC. E2 supplementation reversed the reduction in milk chocolate preference and PFC 5-HT levels. In the hypothalamus, PRS increased ERα and ERβ estrogen receptor and CARTP (cocaine-and-amphetamine receptor transcript peptide) mRNA levels in males, and 5-HT2C receptor mRNA levels in females. Changes were corrected by treatments with finasteride and E2, respectively. These new findings show that early life stress has a profound impact on hedonic sensitivity to high-palatable food via long-lasting changes in gonadal hormones. This paves the way to the development of hormonal strategies aimed at correcting abnormalities in the response to natural rewards.
Databáze: OpenAIRE
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