HFE hemochromatosis screening in patients with severe hip osteoarthritis: A prospective cross-sectional study

Autor:	Oppl, Bastian, Husar-Memmer, Emma, Pfefferkorn, Svea, Blank, Martha, Zenz, Peter, Gollob, Eva, Wurnig, Christian, Engel, Alfred, Stadlmayr, Andreas, Uyanik, Gökhan, Brozek, Wolfgang, Klaushofer, Klaus, Zwerina, Jochen, Datz, Christian
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Male musculoskeletal diseases congenital hereditary and neonatal diseases and abnormalities Heredity Substitution Mutation Iron Overload Genotype lcsh:Medicine Surgical and Invasive Medical Procedures Gastroenterology and Hepatology Biochemistry Severity of Illness Index Homozygosity Osteoarthritis Hip Pelvis Musculoskeletal System Procedures Rheumatology Skeletal Joints Osteoarthritis Medicine and Health Sciences Genetics Humans Arthroplasty Replacement Hemochromatosis Protein lcsh:Science Musculoskeletal System Aged Ferritin Hip Joint Replacement Surgery Arthritis Liver Diseases lcsh:R Biology and Life Sciences Proteins Protein Complexes nutritional and metabolic diseases Middle Aged Mutation Ferritins Female lcsh:Q Hemochromatosis Anatomy Research Article
Zdroj:	PLoS ONE, Vol 13, Iss 11, p e0207415 (2018) PLoS ONE
ISSN:	1932-6203
Popis:	Objective Despite the high frequency of HFE gene mutations in Western Europe, widespread screening for HFE hemochromatosis is not recommended due to its variable phenotype. Joint pain and a premature osteoarthritis-like disease including the hip joints are the most frequent manifestation in patients with HFE hemochromatosis and iron overload. Therefore, screening of patients with severe osteoarthritis of the hip could identify patients with HFE hemochromatosis. Methods In this prospective cross-sectional study, 940 patients aged
Databáze:	OpenAIRE
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