Thresholds for Arterial Wall Inflammation Quantified by 18F-FDG PET Imaging

Autor: Fleur M, van der Valk, Simone L, Verweij, Koos A H, Zwinderman, Aart C, Strang, Yannick, Kaiser, Henk A, Marquering, Aart J, Nederveen, Erik S G, Stroes, Hein J, Verberne, James H F, Rudd
Rok vydání: 2016
Předmět:
Carotid Artery Diseases
Male
Carotid Artery
Common
ROI
region of interest
SUV
standardized uptake value
CVD
cardiovascular disease
PET
positron emission tomography
SUVmax
maximum standardized uptake value
TBRactive slices
percentage having at least 1 active slice
Predictive Value of Tests
Fluorodeoxyglucose F18
Humans
Aorta
Aged
Original Research
Observer Variation
Arteritis
Clinical Trials as Topic
Aortitis
TBR
target to background ratio
18F-FDG PET/CT
thresholds
Reproducibility of Results
imaging
Middle Aged
Plaque
Atherosclerotic
CT
computed tomography
%active slices
percentage of active slices
Carotid Arteries
inflammation
Radiology Nuclear Medicine and imaging
Case-Control Studies
Positron-Emission Tomography
TBRmax
90th percentile of target to background ratio
ICC
intraclass coefficient correlation
Female
Radiopharmaceuticals
atherosclerosis
18F-FDG
18fluorodeoxyglucose
Cardiology and Cardiovascular Medicine
Zdroj: Jacc. Cardiovascular Imaging
ISSN: 1936-878X
DOI: 10.1016/j.jcmg.2016.04.007
Popis: Objectives This study assessed 5 frequently applied arterial 18fluorodeoxyglucose (18F-FDG) uptake metrics in healthy control subjects, those with risk factors and patients with cardiovascular disease (CVD), to derive uptake thresholds in each subject group. Additionally, we tested the reproducibility of these measures and produced recommended sample sizes for interventional drug studies. Background 18F-FDG positron emission tomography (PET) can identify plaque inflammation as a surrogate endpoint for vascular interventional drug trials. However, an overview of 18F-FDG uptake metrics, threshold values, and reproducibility in healthy compared with diseased subjects is not available. Methods 18F-FDG PET/CT of the carotid arteries and ascending aorta was performed in 83 subjects (61 ± 8 years) comprising 3 groups: 25 healthy controls, 23 patients at increased CVD risk, and 35 patients with known CVD. We quantified 18F-FDG uptake across the whole artery, the most-diseased segment, and within all active segments over several pre-defined cutoffs. We report these data with and without background corrections. Finally, we determined measurement reproducibility and recommended sample sizes for future drug studies based on these results. Results All 18F-FDG uptake metrics were significantly different between healthy and diseased subjects for both the carotids and aorta. Thresholds of physiological 18F-FDG uptake were derived from healthy controls using the 90th percentile of their target to background ratio (TBR) value (TBRmax); whole artery TBRmax is 1.84 for the carotids and 2.68 in the aorta. These were exceeded by >52% of risk factor patients and >67% of CVD patients. Reproducibility was excellent in all study groups (intraclass correlation coefficient >0.95). Using carotid TBRmax as a primary endpoint resulted in sample size estimates approximately 20% lower than aorta. Conclusions We report thresholds for physiological 18F-FDG uptake in the arterial wall in healthy subjects, which are exceeded by the majority of CVD patients. This remains true, independent of readout vessel, signal quantification method, or the use of background correction. We also confirm the high reproducibility of 18F-FDG PET measures of inflammation. Nevertheless, because of overlap between subject categories and the relatively small population studied, these data have limited generalizability until substantiated in larger, prospective event-driven studies. (Vascular Inflammation in Patients at Risk for Atherosclerotic Disease; NTR5006)
Graphical abstract Image 1
Databáze: OpenAIRE
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