| Autor: |
Sonia Olivia, Spitzer, Sergey, Sitnikov, Yasmine, Kamen, Kimberley Anne, Evans, Deborah, Kronenberg-Versteeg, Sabine, Dietmann, Omar, de Faria, Sylvia, Agathou, Ragnhildur Thóra, Káradóttir |
| Přispěvatelé: |
Kamen, Yasmine [0000-0003-1867-7397], Kronenberg-Versteeg, Deborah [0000-0003-0965-9998], Karadottir, Thora [0000-0001-9675-2722], Apollo - University of Cambridge Repository |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Neuron |
| Popis: |
Oligodendrocyte progenitor cells (OPCs), which differentiate into myelinating oligodendrocytes during central nervous system (CNS) development, are the main proliferative cells in the adult brain. OPCs are conventionally considered a homogeneous population, particularly with respect to their electrophysiological properties, but this has been debated. We show, by using single-cell electrophysiological recordings, that OPCs start out as a homogeneous population, but become functionally heterogeneous, varying both within and between brain regions and with age. These electrophysiological changes in OPCs correlate with the differentiation potential of OPCs; thus, they may underlie the differentiational differences in OPCs between regions and likewise differentiation failure with age. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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