Clinical Impact of Dose Reductions and Interruptions of Second-Generation Tyrosine Kinase Inhibitors in Patients with Chronic Myeloid Leukaemia
| Autor: | Santos, Fp, Kantarjian, H, Fava, Carmen, O'Brien, S, Garcia Manero, G, Ravandi, F, Wierda, W, Thomas, D, Shan, J, Cortes, J. |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Aged 80 and over Male Adolescent Dasatinib Antineoplastic Agents Middle Aged Protein-Tyrosine Kinases Survival Analysis Article Drug Administration Schedule Thiazoles Young Adult Pyrimidines Treatment Outcome hemic and lymphatic diseases Leukemia Myelogenous Chronic BCR-ABL Positive Humans Female Protein Kinase Inhibitors Aged |
| Popis: | Second (2nd)-generation tyrosine kinase inhibitors (TKI) (dasatinib, nilotinib) are effective in patients with all phases of chronic myeloid leukaemia (CML). Dose reductions and treatment interruptions are frequently required due to toxicity, but their significance is unknown. We analysed the impact of dose reductions/interruptions and dose intensity of 2nd-generation TKI on response and survival. A total of 280 patients with CML (all phases) were analysed. Dose reductions were considered when the daily dose was below the standard dose. Dose intensity was determined based on the percentage of the ideal dose intensity. Overall, 176 patients (63%) required treatment interruptions and/or dose reduction at least once during therapy. Dose reductions/interruptions, analysed as a time-dependent covariate, were associated with worse failure-free survival only in patients with untreated CML. Dose intensity analysis did not reveal a worse response or survival in patients who received a lower dose intensity ( |
| Databáze: | OpenAIRE |
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