HLA-G Is Widely Expressed by Mast Cells in Regions of Organ Fibrosis in the Liver, Lung and Kidney
| Autor: | Mouchet, Nicolas, Vu, Nicolas, Turlin, Bruno, Rioux-Leclercq, Nathalie, Jouneau, Stéphane, Samson, Michel, Amiot, Laurence |
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| Přispěvatelé: | Jonchère, Laurent, H2P2 - Histo Pathologie Hight Precision (H2P2), Université de Rennes (UR)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Plateforme Génomique Santé Biogenouest®, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), CHU Pontchaillou [Rennes], This work was supported by INSERM, The 'Ministère de l’Education Nationale de la Recherche et de la Technologie', the University of Rennes 1, by grants from 'Agence de Biomédecine' (16GZ434-01DX), and Biosit 2020., Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA) |
| Rok vydání: | 2021 |
| Předmět: |
Male
QH301-705.5 [SDV]Life Sciences [q-bio] HLA-G Cell Count mast cells Kidney Article follicles Humans Biology (General) QD1-999 Lung Aged HLA-G Antigens Inflammation B-Lymphocytes fibrosis antifibrotic Middle Aged [SDV] Life Sciences [q-bio] Chemistry Gene Expression Regulation Liver Female B lymphocytes |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, 2021, 22 (22), pp.12490. ⟨10.3390/ijms222212490⟩ Volume 22 Issue 22 International Journal of Molecular Sciences, MDPI, 2021, 22 (22), pp.12490. ⟨10.3390/ijms222212490⟩ International Journal of Molecular Sciences, Vol 22, Iss 12490, p 12490 (2021) |
| ISSN: | 1422-0067 1661-6596 |
| Popis: | We previously demonstrated that mast cells expressing HLA-G are associated with regions of hepatitis C virus-induced liver fibrosis. Here, we aimed to determine whether HLA-G expression in mast cells is specific to viral etiology, the liver, or to the general process of fibrosis. We enumerated HLA-G+ cells and mast cells by the immunohistochemistry of (i) liver blocks from 41 cases of alcoholic cirrhosis, (ii) 10 of idiopathic pulmonary fibrosis (IPF), and (iii) 10 of renal fibrosis. The nature of the HLA-G+ cells was specified by multiplex immunofluorescence using software. More than half of all HLA-G+ cells were mast cells in fibrotic areas of alcoholic cirrhosis and IPF. In the kidneys, subjected to fibrosis, the HLA-G+ cells were indeed mast cells but could not be counted. Moreover, in certain cases of the liver and lung, we observed a number of cellular nodes, which were secondary or tertiary follicles, in which HLA-G was highly expressed by B lymphocytes. In conclusion, HLA-G+ mast cells could be observed in the fibrotic regions of all organs studied. Previous studies suggest a protective role for HLA-G+ mast cells against inflammation and fibrosis. The observed follicles with B lymphocytes that express HLA-G may also reinforce their antifibrotic role. |
| Databáze: | OpenAIRE |
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