Update on neutrophil function in severe inflammation
| Autor: | Mortaz, E, Alipoor, S, Adcock, IM, Mumby, S, Koenderman, L |
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| Přispěvatelé: | Wellcome Trust, British Heart Foundation, Dunhill Medical Trust |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
HUMAN LUNG-CANCER
EXTRACELLULAR-MATRIX PROTEINS Neutrophils Immunology Review Infections Trauma IMMUNE DYSFUNCTION HUMAN EXPERIMENTAL ENDOTOXEMIA severe inflammation SUPPRESSOR-CELLS Animals Humans Immunology and Allergy CD64 innate immunity Inflammation Innate immunity Science & Technology MULTIPLE ORGAN FAILURE GR-1(+) MYELOID CELLS Severe inflammation infection TUMOR-ASSOCIATED NEUTROPHILS trauma SERINE PROTEASES Wounds and Injuries TRAUMA PATIENTS Infection Life Sciences & Biomedicine |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, 9(OCT). Frontiers Media S. A. |
| ISSN: | 1664-3224 |
| Popis: | Neutrophils are main players in the effector phase of the host defense against micro-organisms and have a major role in the innate immune response. Neutrophils show phenotypic heterogeneity and functional flexibility, which highlight their importance in regulation of immune function. However, neutrophils can play a dual role and besides their antimicrobial function, deregulation of neutrophils and their hyperactivity can lead to tissue damage in severe inflammation or trauma. Neutrophils also have an important role in the modulation of the immune system in response to severe injury and trauma. In this review we will provide an overview of the current understanding of neutrophil subpopulations and their function during and post-infection and discuss the possible mechanisms of immune modulation by neutrophils in severe inflammation. |
| Databáze: | OpenAIRE |
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