| Autor: |
Jp, Moxham, Dj, Kibblewhite, Marcel Dvorak, Perey B, Af, Tencer, Ag, Bruce, Dm, Strong |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
Europe PubMed Central |
| ISSN: |
0381-6605 |
| Popis: |
Transforming growth factor-beta 1 (TGF-beta 1) is a polyfunctional regulatory cytokine that has been shown to have roles in extracellular matrix interactions, soft tissue healing, and osteogenesis. This study was undertaken to determine the efficacy of TGF-beta 1 in the formation of functionally normal bone in tibial-diaphyseal defects.Seven hundred fifty micrograms of recombinant human TGF-beta 1 was added to a guanidine-extracted demineralised bone matrix (Gu-DBM) carrier and the implants were used to fill a 2.5 cm tibial diaphyseal defect in skeletally mature female sheep. The defects were allowed to heal over a 12-week period. After sacrifice, they were analyzed using four-point bending mechanical testing.Implants with TGF-beta 1 showed complete bony bridging of the defect and stress-strain curves similar to the normal contralateral limb, while implants with the carrier alone failed to bridge the gap.These results demonstrate the ability of TGF-beta 1 to induce new bone which has structural and functional characteristics similar to normal bone. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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