Barrett's esophagus: prevalence and incidence of adenocarcinomas
| Autor: | Helen M, Shields, Gerardo, Nardone, Jingjing, Zhao, Wen, Wang, Zheng, Xing, Dianchun, Fang, Brian C, Jacobson, Yvonne, Romero, Katerina, Dvorak, Aaron, Goldman, Carlos A, Pellegrini, Elizabeth L, Wiley, David A, Peura, Roger P, Tatum, Thomas G, Schnell |
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| Přispěvatelé: | H. M., Shield, Nardone, GERARDO ANTONIO PIO, J., Zhao, W., Wang, Z., Xing, D., Fang, B. C., Jacobson, Y., Romero, K., Dvorak, A., Goldman, C. A., Pellegrini, E. L., Wiley, D. A., Peura, R. P., Tatum, T. G., Schnell |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Popis: | The following on prevalence and incidence of adenocarcinomas in Barrett's esphophagus (BE) includes commentaries on the mechanisms of a potential protective effect of proton pump inhibitors (PPIs) on progression of BE to high-grade dysplasia; evaluation of the role of PPIs in decreasing the risk of degeneration; the geographical variations of incidence of BE; the role of the nonmorphologic biomarkers; the relationship between length of BE and development of cancer; the confounding factors in incidence rates of BE; the role of the increase of cell differentiation and apoptosis induced by PPIs in the diminution of cancer risk; the frequency of occult neoplastic foci and unsuspected invasive cancer in surgical specimens; the influence on the indications of endoscopic therapy; the overestimation of regression in surgical series; attempts to evaluate the reasons for variations of cancer incidence in the literature; and progress in screening and surveillance for BE. |
| Databáze: | OpenAIRE |
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