Self-reported sleep duration and napping, cardiac risk factors and markers of subclinical vascular disease: cross-sectional study in older men
| Autor: | Zonoozi, Shahrzad, Ramsay, Sheena E, Papacosta, Olia, Lennon, Lucy, Ellins, Elizabeth A, Halcox, Julian P J, Whincup, Peter H, Goya Wannamethee, S |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
Male Time Factors Epidemiology subclinical atherosclerosis Disorders of Excessive Somnolence Pulse Wave Analysis Carotid Intima-Media Thickness Vascular Stiffness Risk Factors Forced Expiratory Volume Natriuretic Peptide Brain von Willebrand Factor Humans Insulin Aged Aged 80 and over Glycated Hemoglobin Heart Failure Research sleep patterns Atherosclerosis Peptide Fragments Troponin Cross-Sectional Studies Asymptomatic Diseases Self Report cardiac function Sleep Biomarkers |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | STUDYOBJECTIVES: Daytime sleep has been associated with increased risk of cardiovascular disease and heart failure (HF), but the mechanisms remain unclear. We have investigated the association between daytime and night-time sleep patterns and cardiovascular risk markers in older adults including cardiac markers and subclinical markers of atherosclerosis (arterial stiffness and carotid intima-media thickness (CIMT)). METHODS: Cross-sectional study of 1722 surviving men aged 71-92 examined in 2010-2012 across 24 British towns from a prospective study initiated in 1978-1980. Participants completed a questionnaire and were invited for a physical examination. Men with a history of heart attack or HF (n=251) were excluded from the analysis. RESULTS: Self-reported daytime sleep duration was associated with higher fasting glucose and insulin levels (p=0.02 and p=0.01, respectively) even after adjustment for age, body mass index, physical activity and social class. Compared with those with no daytime sleep, men with daytime sleep >1 hour, defined as excessive daytime sleepiness (EDS), had a higher risk of raised N-terminal pro-brain natriuretic peptide of ≥400 pg/mL, the diagnostic threshold for HF (OR (95% CI)=1.88 (1.15 to 3.1)), higher mean troponin, reduced lung function (forced expiratory volume in 1 s) and elevated von Willebrand factor, a marker of endothelial dysfunction. However, EDS was unrelated to CIMT and arterial stiffness. By contrast, night-time sleep was only associated with HbA1c (short or long sleep) and arterial stiffness (short sleep). CONCLUSIONS: Daytime sleep duration of >1 hour may be an early indicator of HF. |
| Databáze: | OpenAIRE |
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